全基因组测序在畜禽中应用的研究进展

doi:10.16431/j.cnki.1671-7236.2021.09.032

Abstract

Abstract: In terms of genome research, the whole genome sequencing technology has developed from the first generation sequencing technology to the third generation sequencing technology. Compared with traditional methods, whole genome sequencing has the advantages of more comprehensive, more accurate and more efficient. With the development of sequencing technology and the reduction of cost, whole genome sequencing (WGS) technology has gradually become the most commonly used technology in genome research. The whole genome sequencing has made many achievements in the origin and evolution of livestock and poultry, gene mining of important economic traits, molecular breeding and so on. Through whole genome re sequencing, the regions where copy number variation (CNV) occurs and single nucleotide polymorphism (SNP) variation can be found, which can enrich the existing CNV and SNP database, and provide reference for disease resistance, growth, appetite, metabolic regulation, phenotype, environmental adaptation mechanism and important economic trait genes. This paper focused on the research progress of whole genome sequencing technology in major livestock and poultry, summarized the application of whole genome sequencing in the research of variety genetic diversity, population evolution mechanism and functional gene mining of livestock and poultry, and discussed the existing problems of whole genome sequencing, in order to provide reference for the protection of germplasm resources and molecular breeding practice of livestock and poultry.

Key words: whole genome sequencing; chicken; pig; cattle

CLC Number:

S813

YANG Dezhi, HOU Guanyu, SHI Liguang, CAO Ting, ZHOU Xiong, ZHAO Yanhong. Research Progress on Whole Genome Sequencing in Livestock and Poultry[J]. China Animal Husbandry and Veterinary Medicine, 2021, 48(9): 3403-3414.

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Research Progress on Whole Genome Sequencing in Livestock and Poultry

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