替加环素耐药机制研究进展

doi:10.16431/j.cnki.1671-7236.2020.09.038

Abstract

Abstract: Tigecycline,as a new tetracycline antibiotic,is one of the last lines of defense against carbapenems-producing enterobacter multidrug-resistant infections.In recent years,the emergence of tigecycline-resistant strains has severely restricted the clinical use of tigecycline.It was originally believed that the resistance mechanism of tigecycline was mediated by the efflux pump encoded by the chromosome,which could not lead to drug resistance by horizontal transfer.With the deepening of research,it was found that some efflux pump mutations or high expression on the plasmid could also cause the strain's tigecycline sensitivity to decrease.Recently,it has been reported that the plasmid-mediated tet(X) variant can make the strain highly resistant to tigecycline,and can be spread among different species of bacteria through adaptable plasmids.This article described the prevalence and transmission mechanism of high-level tigecycline resistance gene tet(X) variants by introducing bacterial chromosome-mediated tigecycline resistance mechanisms and plasmid-mediated tigecycline resistance mechanisms,and provided a reasonable explanation for the high-level variant of the tigecycline resistance gene tet(X) in animal-derived strains,aiming to provide reference for relevant scientific researchers and clinical workers.

Key words: tigecycline; resistance mechanism; efflux pump; plasmid; tet(X) variations

CLC Number:

S852.6

WANG Liangliang, WANG Qianqian, ZHOU Bolun, JIA Yixin, WU Hua, YUAN Li, HU Gongzheng, HE Dandan. Advance on the Tigecycline Resistance Mechanism[J]. China Animal Husbandry and Veterinary Medicine, 2020, 47(9): 3022-3029.

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Advance on the Tigecycline Resistance Mechanism

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