Abstract: Lactic acid bacteria is widely used to express exogenous gene for its safety and simple operation. In food, agriculture and pharmaceutical engineering has broad application prospects, and developed series of food-grade gene expression system of lactic acid bacteria. Now the sugar-induced expression system, phage φ31 explosive inducible expression system, nisin expression system and temperature-controlled expression system have been established. With the development of technique for gene engineering, an era will come that with recombinant lactic acid bacteria as a genetically engineered bacteria.

Key words: lactic acid bacteria; food-grade; expression system; genetic engineering