Abstract: Mitochondrial permeability transition pore (MPTP) is a non-selective inner membrane channel located in mitochondrion.MPTP triggers mitochondrial permeability transition,resulting in the release of apoptotic factor ,for example cytochrome C,apoptosis inducing factor (AIF),Ca²⁺ and procaspase, cell structure destroyed and function disordered , finally apoptosis. Formerly，MPT is considered the key for cell apoptosis,but the recent research show there is no evitable relationship. The review focuses on the biological function of MPT,adenine nucleotide translocatar(ANT),Cyp D and the relationship of orientation,distribution of Bcl-2 family with MPT.

Key words: mitochondrial permeability transition; cell apoptosis