China Animal Husbandry & Veterinary Medicine ›› 2012, Vol. 39 ›› Issue (5): 107-110.

• 生理生化 • Previous Articles     Next Articles

Influence of Substituent on the Anti-inflammatory Effect of Flavonoids against Lipopolysaccharide-induced Nitric Oxide

YANG Yao-zhi, TANG You-zhi, CHEN Jian-xin   

  1. The Guangdong Provincial Key laboratory of Veterinary Drugs' Research and Safety Evaluation, College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China
  • Received:2011-11-24 Revised:1900-01-01 Online:2012-05-20 Published:2012-05-20

Abstract: Aim to provide experimental data for the research and development of flavonoids as non-steroidal anti-inflammatory drugs (NSAIDS),the substituent effects on the anti-inflammatory effect of five flavonoids against lipopolysaccharide (LPS)-induced nitric oxide (NO) have been studied. Flavone (FLA),5,7-dihydroxyflavone (DFL),5,7,4'-trihydroxyflavone (TFL),apigenin-7-glucoside (APG) and linarin (LIN) were carried out to investigate for anti-inflammatory effects against LPS-induced NO. TFL significantly inhibited generation of NO on LPS stimulated RAW264.7 cells. The 4'-OH was essential for the anti-inflammatory effect of TFL against LPS-induced NO.

Key words: flavonoids; 4'-Trihydroxyflavone; macrophage; NO

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