精子发生及冷冻过程中表观遗传调控的研究进展

Abstract

Abstract: Epigenetics modification is the heritable changes in gene activity which are not involved in changes in the DNA sequences, including DNA methylation and chromatin remodeling, histone modification and non-coding RNAs, which plays important roles in gene expression, spermatogenesis, development and maturation. During spermatogenesis, normal morphology, motility and fertility were proven to be modulated by epigenetic changes. Cryopreservation causes dramatic changes of the sperm viability, motility and fertility, and the cryoinjury might be involved in some epigenetic factors. The epigenetic modifications involved in spermatogenesis and cryopreservation and their relationship were reviewed.

Key words: spermatogenesis; cryopreservation; epigenetic modification

CLC Number:

S814.8

PENG Wen-pei, ZENG Chang-jun. Research Progress on Epigenetic Modifications during Spermatogenesis and Cryopreservation[J]. , 2014, 41(9): 199-205.

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