ART3功能及其与精子发生关系的研究进展

doi:10.16431/j.cnki.1671-7236.2023.08.019

Abstract

Abstract: ADP ribosyl transferase 3(ART3) is an ADP-ribosyl transferases,which is highly associated with nonobstructive azoospermia and cancer.Generally,interference with the ART3 gene or inhibition of the protein encoded by the gene results in low sperm density,high malformation rate and the spermatogenic cells in the seminiferous tubules fall off.It shows that ART3 is indispensable in spermatogenesis,and it is necessary to further study its function.At present,the specific roles of ART3 in spermatogenesis is unclear yet and there is very little reports on it.The author reviewed the protein structures of ARTs family members and their roles in spermatogenesis,the results of ART3 protein structure prediction and its localization in testicular tissue,and also summarized the ART3 functions in the pathogenesis of triple negative breast cancer and melanoma and the regulatory pathways in which ART3 had been involved.The review might serve as a scientific reference to help in unveiling the functions of ART3 in spermatogenesis,which might provide insight into the improvement of semen quality and the solutions to male sterility.

Key words: ADP-ribosyl transferase(ART3); spermatogenesis; subcellular localization; semen quality

CLC Number:

S814.4

XU Shiyuan, ZHANG Qiuxue, ZHAO Lingjun, DONG Zhihao, LIU Songqi, YUAN Kaimin, WU Kaihui, WANG Dong. Research Progress on the Function of ART3 and Its Relationship with Spermatogenesis[J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(8): 3221-3228.

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Research Progress on the Function of ART3 and Its Relationship with Spermatogenesis

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