P21基因与哺乳动物器官再生相关性研究进展

Abstract

Abstract: Animals’capability of regenerating multiple tissue types, organs, and appendages after injury are common among invertebrates and urodele amphibians, but notably such regenerative capacity is rare in mammals. Recently, accumulating evidence has proved that mammals may also have regenerative property with the discovery of MRL mouse, and it brings new hope for clinical therapies. The regeneration of appendages depends on cells proliferation, at the same time, cells proliferation depends on cell cycle, so as one of the cell cycle regulatory proteins, we found the deletion of P21 gene could actually result in full MRL epimorphic regeneration phenotype in a new study, providing a firm link between p21 protein and tissue regeneration. This article reviewed the fields of tissue regeneration and p21 protein, and introduced the relationship between tissue regeneration and p21 protein.

Key words: font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-bidi-font-size: 12.0pt; mso-font-kerning: 1.0pt; mso-ansi-language: EN-US; mso-fareast-language: ZH-CN; mso-bidi-language: AR-SA" lang="EN-US">regeneration; font-size: 10.5pt; mso-bidi-font-family: 宋体; mso-bidi-font-size: 12.0pt; mso-font-kerning: 1.0pt; mso-ansi-language: EN-US; mso-fareast-language: ZH-CN; mso-bidi-language: AR-SA" lang="EN-US">Pfont-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-bidi-font-size: 12.0pt; mso-font-kerning: 1.0pt; mso-ansi-language: EN-US; mso-fareast-language: ZH-CN; mso-bidi-language: AR-SA" lang="EN-US">21 gene; mammals; MRL

GUO Qian-qian, WANG Da-tao, CHU Wen-hui, ZHAO Hai-ping, SUN Hong-mei, LI Chun-yi. Research Progress of Relationship between P21 Gene and Mammalian Regeneration[J]. .

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Research Progress of Relationship between P21 Gene and Mammalian Regeneration

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