Abstract: In order to understand the effect of Oxytropis glabra on the structure of liver tissue and observe the effect of antidote on the detoxification in mice，30 mice were randomly divided into 5 groups，the control group was fed with basal diet, group 1 was fed with basal diet supplemented with Oxytropis glabra，group 2 was gavaged alkaloid solution extracted from Oxytropis glabra，group 3 was fed with basal diet supplemented with Oxytropis glabra and injected antidote into intraperitoneal simultaneously，group 4 was gavaged alkaloid solution extracted from Oxytropis glabra and injected antidote into intraperitoneal simultaneously. The mice were fed in single cage，and the trial lasted for 21 days.The results showed that the different degree of hyperemia and hemorrhage were appeared in liver and kidney tissue of groups 1 and 2.Most of the liver cells in hepatic lobule were swelled and vacuoles degenerated.The organ coefficient analysis showed that there were significant differences （P＜0.05） or extremely significant differences （P＜0.01） between the detoxification groups and the poisoned groups.In couclusion，the antidote had a certain protective effect for liver tissue damage caused by Oxytropis glabra and its alkaloids.

Key words: Oxytropis glabra; mice; pathological observation; organ coefficient