细胞色素P450 2E1的研究进展

Abstract

Abstract: Cytochrome P450 2E1 (CYP2E1) is one of the body's metabolite of drugs and low molecular weight compounds mainly enzymes, and the increasing of activity or expression of CYP2E1 is closely related with the clinical variety of diseases. This paper reviews the research progress of protein structure, function, positioning mechanism and other aspects of genetic polymorphisms of CYP2E1 at home and abroad. Thereby the paper could lay the foundation for further exploration of the biological effects of CYP2E1 and its relationship with clinical disease.

Key words: cytochrome P450 2E1 (CYP2E1); protein structure; function; gene polymorphism; liver toxicity

CLC Number:

R963

WU Shu-qin, WANG Cheng-shuang, WANG Xin, LI Peng. Research Progress on Cytochrome P450 2E1[J]. China Animal Husbandry & Veterinary Medicine, 2014, 41(11): 165-170.

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Research Progress on Cytochrome P450 2E1

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