细胞色素P450 2E1的研究进展

Abstract

Abstract: Cytochrome P450 2E1 (CYP2E1) is one of the body's metabolite of drugs and low molecular weight compounds mainly enzymes, and the increasing of activity or expression of CYP2E1 is closely related with the clinical variety of diseases. This paper reviews the research progress of protein structure, function, positioning mechanism and other aspects of genetic polymorphisms of CYP2E1 at home and abroad. Thereby the paper could lay the foundation for further exploration of the biological effects of CYP2E1 and its relationship with clinical disease.

Key words: cytochrome P450 2E1 (CYP2E1); protein structure; function; gene polymorphism; liver toxicity

CLC Number:

R963

WU Shu-qin, WANG Cheng-shuang, WANG Xin, LI Peng. Research Progress on Cytochrome P450 2E1[J]. , 2014, 41(11): 165-170.

References

1 王春花,成军,郎振为,等. 细胞色素CPYⅡE1与肝脏疾病关系的研究进展[J]. 世界华人消化杂志,2004,12(4):950～954.
2 王悦之,张玉. CYP2E1与非酒精性脂肪肝[J]. 胃肠病学和肝病学杂志,2012,21(4):384～386.
3 王媛媛,曹玉珍,徐国峰,等. 细胞色素P4502A5研究概述[J]. 中国畜牧兽医,2010,36(7):40～43.
4 冯亮,张会瑞,吕彦东,等. 细胞色素P450 2E1基因PstⅠ/RsaⅠ多态性与结直肠癌易感关系的Meta分析[J]. 中国组织工程研究,2012,16(11):2080~2083.
5 卢永科. 细胞色素P450 2E1增强顺铂肝毒性的机理研究[D]. 大连:大连医科大学,2008.
6 刘芳,朱新林,陆荣柱. 细胞色素P450 2E1在线粒体的定位、功能、调节因素及其毒理学意义[J]. 卫生研究,2013,42(4):706～711.
7 刘芳. 细丙烯晴对大鼠肝脏线粒体CYP2E1的影响研究[D]. 镇江:江苏大学,2013.
8 刘树民,张琳,李颖,等. 黄药子与当归配伍对大鼠肝脏CYP1A2、CYP2E1基因mRNA表达的影响[J]. 中药药理与临床,2006,22(3):97～98.
9 张放,邵华,张志虎,等. 毒物代谢酶CYP2E1基因多态性对苯乙烯代谢的影响[J]. 中国工业医学杂志,2010,23(12):412～414.
10 李珏. 细胞色素酶CYP2E1与芳香族底物结合的生物信息与结构生物学研究[D]. 上海:上海交通大学,2011.
11 陈大健,江善祥,杨海峰,等. 几种药物对鲫鱼肝微粒体细胞色素P450酶系的影响[A]. 中国畜牧兽医学会兽医药理毒理学分会第九次学术讨论会论文与摘要集[C].2006.
12 林钟婷,朱静,翁银标,等. 热休克蛋白70的研究进展[J]. 中国畜牧兽医,2007,34(3):67～70.
13 郑波,刘建军. CYP1A1、CYP2E1基因多态性与癌症易感性的研究进展[J]. 癌变·畸变·突变,2010,22(3):243～245.
14 胡东华,王宇光,陈志武,等. 复方丹参方对大鼠心脏细胞色素P450酶的影响[J]. 中草药,2014,45(1):75～80.
15 秦国华,孟紫强.二氧化硫对大鼠肝和肺细胞色素P4502B1和2E1 mRNA表达及活性的影响[J]. 卫生研究,2006,35(5):554～556.
16 燕速,白振忠,赵健信,等. CYP2E1 DraⅠ基因遗传多态性与青海省胃癌人群易感性的相关性研究[J]. 中国癌症杂志,2013,23(4):273～278.
17 Anandatheerthavarada H K, Sepuri N B V, Avadhani N G. Mitochondrial targeting of cytochrome P450 proteins containing NH2-terminal chimeric signals involves an unusual TOM20/TOM22 by pass mechanism[J]. Journal of Biological Chemistry, 2009, 284(25): 17352～17363.
18 Armoni M, Harel C, Ramdas M, et al. CYP2E1 impairs GLUT4 gene expression and function: NRF2 as a possible mediator[J]. Hormone and Metabolic Research, 2014, 46(7): 477～483.
19 Avadhani N G, Sangar M C, Bansal S, et al. Bimodal targeting of cytochrome P450s to endoplasmic reticulum and mitochondria: The concept of chimeric signals[J]. FEBS Journal, 2011, 278(22): 4218～4229.
20 Bansal S, Srinivasan S, Anandasadagopan S, et al. Additive effects of mitochondrion-targeted cytochrome CYP2E1 and alcohol toxicity on cytochrome coxidase function and stability of respirosome complexes[J]. Journal of Biological Chemistry, 2012, 287(19): 15284～15297.
21 Caro A A, Cederbaum A I. Oxidative stress, toxicology, and pharmacology of CYP2E1[J]. Annu Rev Pharmacol Toxicol, 2004, 44: 27～42.
22 Chong E T J, Lee C C, Chua K H, et al. RsaⅠbut not Dra Ⅰ polymorphism in CYP2E1 gene increases the risk of gastrointestinal cancer in Malaysians: A case-control study[J]. BMJ Open, 2014, 4(1): e004109.
23 Dai F G, Luo R, Wang Y G, et al.Compatible effects of euphorbia and glycyrrhiza on CYP2E1 expression and activity in rat liver[J].Aeta Aead Med Med Mil Tert, 2005, 27(8): 742～744.
24 Feng J, Pan X, Yu J, et al. Functional Pst Ⅰ/Rsa Ⅰ polymorphism in CYP2E1 is associated with the development, progression and poor outcome of gastric cancer[J]. PLoS One, 2012, 7(9): e44478.
25 Gonzalez F J. The 2006 Bernard B. Brodie award lecture. CYP2E1[J]. Drug Metab Dispos, 2007, 35(1): 1～8.
26 Harbauer A B, Zahedi R P, Sickmann A, et al. The protein import machinery of mitochondria——A regulatory hub in metabolism, stress, and disease[J]. Cell Metabolism, 2014, 19(3): 357～372.
27 Ingelman-Sundberg M. Human drug metabolising cytochrome P450 enzymes: Properties and polymorphisms[J]. Naunyn-Schmiedeberg's Archives of Pharmacology, 2004, 369(1): 89～104.
28 Kalyaanamoorthy S, Chen Y P P. Modelling and enhanced molecular dynamics to steer structure-based drug discovery[J]. Progress in Biophysics and Molecular Biology, 2014, 114(3): 123～136.
29 Knockaert L, Descatoire V, Vadrot N, et al. Mitochondrial CYP2E1 is sufficient to mediate oxidative stress and cytotoxicity induced by ethanol and acetaminophen[J]. Toxicology in Vitro, 2011, 25(2): 475～484.
30 Knockaert L, Fromenty B, Robin M A.Mechanisms of mitochondrial targeting of cytochrome P4502E1: Physiopathological role in liver injury and obesity[J].FEBS J, 2011, 278(22): 4252～4260.
31 Kuuranne T, Saugy M, Baume N. Confounding factors and genetic polymorphism in the evaluation of individual steroid profiling[J]. British Journal of Sports Medicine, 2014, 48(10): 848～855.
32 Lakkakula S, Maram R, Munirajan A K, et al. Functional Pst Ⅰ/Rsa Ⅰ Polymorphisms in the CYP2E1 gene among south Indian populations[J]. Asian Pacific Journal of Cancer Prevention, 2013, 14(1): 179～182.
33 Le Marchand L, Donlon T, Seifried A, et al. Red meat intake, CYP2E1 genetic polymorphisms, and colorectal cancer risk[J]. Cancer Epidemiology Biomarkers & Prevention, 2002, 11(10): 1019～1024.
34 Lewis D F. Quantitative structure-activity relationships (QSARs) for substrates of human cytochromes P450 CYP2 family enzymes[J]. Toxicol in Vitro, 2004, 18(1): 89～97.
35 Liu Y, Liu B Y, Hao P, et al. π-π Stacking mediated drug-drug interactions in human CYP2E1[J]. Proteins: Structure, Function, and Bioinformatics, 2013, 81(6): 945～954.
36 Oh S J,Choi J M, Yun K U, et al. Hepatic expression of cytochrome P450 in type 2 diabetic Goto-Kakizaki rats[J]. Chemico-biological Interactions, 2012, 195(3): 173～179.
37 Park B K, Kitteringham N R, Maggs J L, et al. The role of metabolic activation in drug-induced hepatotoxicity[J]. Annu Rev Pharmacol Toxicol, 2005, 45: 177～202.
38 Porubsky P R, Battaile K P, Scott E E. Human cytochrome P4502E1 structures with fatty acid analogs reveal a previously unobserved binding mode[J]. Journal of Biological Chemistry, 2010, 285(29): 22282～22290.
39 Rocejanasaro J A, Tencomnao T, Sangkitikomol W. Thunbergia laurifolia extract minimizes the adverse effects of toxicants by regulating P-glycoprotein activity, CYP450, and lipid metabolism gene expression in HepG2 cells[J]. Genetics and Molecular Research: GMR, 2014, 13(1): 205.
40 Sakaguchi M, Mihara K, Sato R. Signal recognition particle is required for co-translational insertion of cytochrome P-450 into microsomal membranes[J]. Proceedings of the National Academy of Sciences, 1984, 81(11): 3361～3364.
41 Sepuri N B V, Yadav S, Anandatheerthavarada H K, et al. Mitochondrial targeting of intact CYP2B1 and CYP2E1 and N-terminal truncated CYP1A1 proteins in Saccharomyces cerevisiae- role of protein kinase A in the mitochondrial targeting of CYP2E1[J]. FEBS Journal, 2007, 274(17): 4615～4630.
42 Shan S. Fidelity of substrate targeting by the signal recognition particle system[J]. Annual Review of Biophysics, 2014, 43(1): 381～408.
43 Smith S V, Robinson R C, Smith T G, et al. Rapid conformational dynamics of cytochrome P4502E1 in a natural biological membrane environment[J]. Biochemistry, 2006, 45(51): 15617～15623.
44 Trafalis D T, Panteli E S, Grivas A, et al. CYP2E1 and risk of chemically mediated cancers[J]. Expert Opinion on Drug Metabolism & Toxicology, 2010, 6(3): 307～319.
45 Vaglini F, Viaggi C, Piro V, et al. Acetaldehyde and parkinsonism: Role of CYP450 2E1[J]. Frontiers in Behavioral Neuroscience, 2013, 7: 11.
46 Ou W J, Ito A, Morohashi K, et al. Processing-independent in vitro translocation of cytochrome P-450 (SCC) precursor across mitochondrial membranes[J]. Journal of Biochemistry, 1986, 100(5): 1287～1296.
47 Yun J W, Son M J, Abdelmegeed M, et al. Binge alcohol promotes acute liver injury through a CYP2E1-HIF-1α-dependent apoptosis pathway in mice and humans[J]. Free Radic Bio Med, 2014,77:183~194.
48 Zaher H, Buters J, Ward J M, et al. Protection against acetaminophen toxicity in CYP1A2 and CYP2E1 double-null mice[J]. Toxicology and Applied Pharmacology, 1998, 152(1): 193～199.

[1]	WU Xuan, ZENG Shenming. Research Progress on the Function,Application and Purification Technology in Serum Albumin [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(6): 2265-2275.
[2]	FAN Bingfeng, LI Wen, LIU Lixiang, ZHAO Xiangyuan, SHAO Jing, LIN Lefeng, SUN Huimin, ZHANG Xulin, XU Baozeng. Cloning and Bioinformatics Analysis of AANAT Gene in Mink [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(4): 1307-1318.
[3]	HU Honglian, LI Chao, CHEN Liqing, SONG Liwen, ZHAO Meng, ZHANG Jianxia, WANG Dian, GAO Min. Effects of Dietary β-carotene Supplementation on Lactation Performance, Blood Routine,Serum Biochemical and Immune Indexes of Dairy Cows during the Lactating Peak Period [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(4): 1375-1384.
[4]	LIU Zhen, ZHOU Xueqin, XU Fei, LI Zhefeng, SUN Hanxue, LI Guoqin, TAO Zhengrong, GUAN Mei, ZHENG Qiang, DIAO Xinping, LU Lizhi. Effects of Coated Sodium Butyrate on Growing Performance,Slaughter Performance, Immune Organ Index and Digestive Enzyme Activity of Breeding Pigeons and Squabs [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(3): 998-1006.
[5]	LIU Zhenni, LEI Xiaowen, LI Jianjun, ZENG Qingyuan, TAN Donghai, ZHONG Yunping, ZHANG Qiang, XIE Hualiang. Effects of Fermented Navel Orange Pomace on Intestinal Morphology,Intestinal Mucosal Immune Function and Microbial Diversity of Muscovy Ducks [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(2): 573-585.
[6]	ZHAO Luyuan, ZOU Chenhao, CAO Jiu'ai, GUO Yanshan, LIU Lijun, ZHAN Xiu'an, LIN Gang, LIU Bing, YU Dongyou. Effects of Low Level of Compound Organic Trace Minerals on Serum Biochemistry,Immune Function and Antioxidant Capacity of Meat Ducks [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(1): 86-96.
[7]	CHEN Jun, CAI Haiming, LIAO Shenquan, QI Nanshan, LI Juan, LYU Minna, LIN Xuhui, HU Junjing, ZHANG Jianfei, LIU Wenjun, SUN Mingfei. Review on the Research of DNA Helicase Family in Parasitic Protozoa [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(1): 317-327.
[8]	ZHANG Hao, LIU Yixuan, ZHU Huiyuan, ZHANG Pengwei, LEI Yanru, GAO Chaoqun, LI Donghua, KANG Xiangtao. Bioinformatics Analysis of Differential Genes of Skin Feather Follicles in Chickens [J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(9): 3273-3282.
[9]	WANG Shuaijie, TAN Zihan, LI Hanbo, SUN Xiangxue, AI Sihan, WANG Lei, ZHAO Di, HOU Yongqing. Effects of Quercetin on Intestinal Morphology, Antioxidant Function and Jejunal Lipid Metabolism Gene Expression in Piglets with Porcine Epidemic Diarrhea Virus [J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(9): 3391-3399.
[10]	LI Zhuojun, CHEN Chunxiang, ZHONG Xiaoju, GAO Jun. Research Progress on Porcine Gut Microbiota Composition, Influencing Factors and Its Effects on Economically Important Traits [J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(7): 2557-2566.
[11]	LI Hongying, HE Qin, HUANG Enfu, LIANG Qi. Effects of Plant Essential Oils on Immune Function, Antioxidant Capacity and Gut Microbiota of Shan Partridge Ducks [J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(7): 2586-2592.
[12]	MEI Huadi, TIAN Qi, QU Shengfu, GAO Fengxian, MA Xianyong, LI Zhenming, LUO Xuehui, YU Miao. Physiological Function of Quercetin and Its Application in Chickens Production [J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(6): 2116-2128.
[13]	YUE Fuyuan, ZHU Lianqin, CHEN Fu, ZHANG Beibei, ZHU Fenghua. Effects of Organic Organically Modified Montmorillonite Added to Mildew Feed on Growth Performance and Immune Function in Chicks [J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(6): 2137-2144.
[14]	XIE Shuqiong, MA Shilong, TANG Jiao, LIU Yili, JIANG Mingfeng. Sequencing Analysis of Full-length Transcriptome of Abomasum in Yak [J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(5): 1610-1620.
[15]	LI Qilong, CHEN Xiangnan, LONG Feng, CHEN Jiayue, YANG Sen, WANG Jing, ZAN Linsen, CHENG Gong. Research Progress in Function of Snail Family Genes [J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(4): 1287-1294.

Research Progress on Cytochrome P450 2E1

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments