Abstract: As the fourth generation of aminothiazolyl cephalosporin,cefquinome was developed especially for using in animals, and a new drug for animal severe infection, which had antibacterial mechanism and antibacterial activity. Cefquinome was known as broad antibacterial spectrum, strong antibacterial activity, superior pharmacokinetics, and no carcinogenicity, mutagenicity, teratogenicity, reproductive toxicity. The blood concentration of cefquinome reached its peak in short time, and had high concentration. The paper summarized the cefquinome’s antibacterial activity, physicochemical properties and pharmacological properties, synthetic routes, a number of problems in synthesizing cefquinome, such as low yield and post treatment difficult were also analyzed, to lead pharmaceutical scientific worker with thorough knowledge and guide clinical application.

Key words: cefquinome; 5,6,7,8-tetrahydroquinoline; pharmacological properties; synthesis