Abstract: The experiment was aimed to establish the mice model of subacute kidney injury induced by gentamycin (GM), and study the effects of saccharum alhagi which was Uighur medicine on nephrotoxicity caused by gentamicin. Twenty eight mice were divided into 7 groups, group A(125 mg/kg GM), group B(100 mg/kg GM), group C(80 mg/kg GM), group D(125 mg/kg GM+saccharum alhagi), group E(100 mg/kg GM+saccharum alhagi),group F(80 mg/kg GM+saccharum alhagi) and group G(saline), respectively, intraperitoneally injected for 7 d. Mice were sacrificed at 8 d after blood collection. The blood was measured for concentration of non-protein nitrogen (NPN) and the weight of livers, spleens and kidneys. The results showed that compared with group A and C respectively, concentration of NPN and kidney coefficients of group D and group F had significant difference(P<0.05); compared with group B, concentration of NPN of group E had no significant difference(P>0.05), but kidney coefficients had significant difference(P<0.05). Kidney damage was found in the groups A, B and C. Saccharum alhagi had palyed an extremly role in the protection of kidney injury induced by 125 and 80 mg/kg GM, but didn't play a significant role in the protection of kidney injury induced by 100 mg/kg GM.

Key words: saccharum alhagi; gentamicin; protective effect; nephrotoxicity