Abstract: The pharmacokinetics of cefquinome sulfate were investigated following single intravenous (IV) and oral administration at a dosage of 10 and 20 mg/kg, respectively, in healthy duck. 20 ducks were randomly divided into two groups for the experiments. The cefquinome sulfate in plasma was determined by reverse phase high performance liquid chromatography (PR-HPLC).The concentration-time data of cefquinome sulfate was analyzed with pharmacokinetic-compartment analysis soft (3P97). The concentration-time data of cefquinome sulfate after IV admistration was fitted to a two-compartment open model. The main pharmacokinetic parameters were as follows, V(c),(1.146±0.02)L/kg; t_1/2α,(0.290±0.02)h; t_1/2β,(1.691±0.15)h; AUC,(6.635±0.18)(mg·h)/L,CL(s),(1.508±0.04)L/(kg·h). The concentration-time data of cefquinome sulfate after oral admistration was fitted to a one-compartment open model with first-order absorbtion. The main pharmacokinetic parameters were as follows,t_1/2(ka),(0.45±0.05)h; t_1/2(ke),(0.96±0.29)h; T_(peak),(0.91±0.09)h; C_(max),(3.14±0.64)mg/L; AUC,(8.29±1.26)(mg·h)/L; F,(62.55±0.10)%. The results showed that the pharmacokinetic characteristics of cefquinome sulfate in healthy duck manifested the rapid absorbtion, wide distribution, rapid elimination but low bioavailability, probably due to its low lipsoluble characteristic. However cefquinome sulfate in blood could keep efficient concentration ((0.14±0.03) to (3.14±0.64)μg/mL) in 8 h, which could inhibit infections of Riemerella anatipestifer (RA) and other bacteria.

Key words: cefquinome sulfate; pharmacokinetics; HPLC; duck