哺乳动物肠道干细胞与Wnt信号通路研究进展

Abstract

Abstract: Intestinal stem cells (ISCs), a kind of cells which located in the gastrointestinal tract have ability of continuous proliferation and differentiation. Wnt signaling pathway is an embryonic development and cancer-related protein networks which first discovered in Drosophila, the pathway maintains the intestines in a multi-level regulation of the steady state. This article outlines research progress in the field of intestinal stem cells, the function of Wnt signaling pathway, understand intestinal stem cells involved in the pathological inflammatory process, then reveal dysplasia and the molecular mechanisms of chronic inflammation which leads to cancer.

Key words: mammalian; intestinal stem cells; Wnt signaling pathway

CLC Number:

ZHANG Qing-dong, ZHANG Cheng-juan, DAI Ye. Progress on Wnt Pathway in Mammalian Intestinal Stem Cells[J]. , 2013, 40(11): 121-125.

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Progress on Wnt Pathway in Mammalian Intestinal Stem Cells

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