动物乳腺干细胞的研究进展

Abstract

Abstract: Mammary stem cells (MaSCs) possess the ability to generate all differentiated cell types in the mammary gland.During the process of mammary development,MaSCs are critical for the growth and reconstruction of mammary tissue in puberty,pregnancy stage,lactation and lactation recession stage.The MaSCs under in vitro culture are ideal experimental model for studying the proliferation,differentiation,survival and apoptosis of mammary cells,and potential approach for producing mammary gland bioreactor.Therefore,the researches about MaSCs are of great importance to the understanding of mammary development,therapy of mammary cancer and agricultural production.This paper will give a systematic review for the localization,purification and in vitro culture of MaSCs,and show prospects of the researches and applications about MaSCs.

Key words: mammary stem cell; localization; purification; mammosphere; mammary gland bioreactor

CLC Number:

R329

SONG Jia-zhe, LI Ning, XUE Kai. Study Progress of Mammary Stem Cells in Animal[J]. , 2013, 40(11): 110-114.

References

1 王珊珊,闫峰,赵小丽,等.干细胞的研究进展[J].中国畜牧兽医,2010,37(5):44~46.
2 朱孟芝,董雅娟,龚宜超,等.体外诱导牛骨髓间充质干细胞向乳腺样上皮细胞分化的初步研究[J].中国畜牧兽医,2010,37(1):92~96.
3 Alvi A J,Clayton H,Joshi H,et al.Functional and molecular characterization of mammary side population cells[J].Breast Cancer Res,2003,5:R1~R8.
4 Bai L X,Rohrschneider L R.s-SHIP promoter expression marks activated stem cells in developing mouse mammary tissue[J].Genes Development,2010,24:1882~1892.
5 Cremers N,Deugnier M A,Sleeman J.Loss of CD24 expression promotes ductal branching in the murine mammary gland[J].Cellular and Molecular Life Sciences,2010,67:2311~2322.
6 DeOme K B,Faulkin L J,Bern H A,et al.Development of mammary tumors from hyperplastic alveolar nodules transplanted into gland-free mammary fat pads of female C3H mice[J].Cancer Research,1959,19(5):515.
7 Dontu G,Abdallah W M,Foley J M,et al.In vitro propagation and transcriptional profiling of human mammary stem/progenitor cells[J].Genes Development,2003,17:1253~1270.
8 Faraldo M M,Deugnier M A,Lukashev M,et al.Perturbation of β1-integrin function alters the development of murine mammary gland[J].The EMBO Journal,1998,17:2139~2147.
9 Goodell M A,Brose K,Paradis G,et al.Isolation and functional properties of murine hematopoietic stem cells that are replicating in vivo[J].The Journal of Experimental Medicine,1996,183(4):1797~1806.
10 Gudjonsson T,Villadsen R,Nielsen H L,et al.Isolation,immortalization,and characterization of a human breast epithelial cell line with stem cell properties[J].Genes Development,2002,16(6):693~706.
11 Jones P H,Harper S,Watt F M.Stem cell patterning and fate in human epidermis[J].Cell,1995,80(1):83~93.
12 Kaur P,Li A.Adhesive properties of human basal epidermal cells:An analysis of keratinocyte stem cells,transit amplifying cells,and postmitotic differentiating cells[J].Journal of Investigative Dermatology,2000,114:413~420.
13 Kenney N J,Smith G H,Lawrence E,et al.Identification of stem cell units in the terminal end bud and duct of the mouse mammary gland[J].BioMed Research International,2001,1(3):133~143.
14 Kiel M J,He S H,Ashkenazi R,et al.Haematopoietic stem cells do not asymmetrically segregate chromosomes or retain BrdU[J].Nature,2007,449:238~242.
15 Kordon E C,Smith G H.An entire functional mammary gland may comprise the progeny from a single cell[J].Development,1998,125(10):1921~1930.
16 Li N,Zhang Y,Naylor M J,et al.β1 integrins regulate mammary gland proliferation and maintain the integrity of mammary alveoli[J].The EMBO Journal,2005,24:1942~1953.
17 Nielsen T O,Hsu F D,Jensen K,et al.Immunohistochemical and clinical characterization of the basal-like subtype of invasive breast carcinoma[J].Clinical Cancer Research,2004,10(16):5367~5374.
18 Péchoux C,Gudjonsson T,Rnnov-Jessen L,et al.Human mammary luminal epithelial cells contain progenitors to myoepithelial cells[J].Developmental Biology,1999,206(1):88~99.
19 Rietze R L,Valcanis H,Brooker G F,et al.Purification of a pluripotent neural stem cell from the adult mouse brain[J].Nature,2001,412(6848):736~739.
20 Shackleton M,Vaillant F,Simpson K J,et al.Generation of a functional mammary gland from a single stem cell[J].Nature,2006,439(7072):84~88.
21 Sleeman K E,Kendrick H,Ashworth A,et al.CD24 staining of mouse mammary gland cells defines luminal epithelial,myoepithelial/basal and non-epithelial cells[J].Breast Cancer Research,2005,8(1):R7.
22 Smith G H.Label-retaining epithelial cells in mouse mammary gland divide asymmetrically and retain their template DNA strands[J].Development,2005,132(4):681~687.
23 Spike B T,Engle D D,Lin J C,et al.A mammary stem cell population identified and characterized in late embryogenesis reveals similarities to human breast cancer[J].Cell Stem Cell,2012,10(2):183~197.
24 Stingl J,Eaves C J,Zandieh I,et al.Characterization of bipotent mammary epithelial progenitor cells in normal adult human breast tissue[J].Breast Cancer Research and Treatment,2001,67(2):93~109.
25 Stingl J,Eirew P,Ricketson I,et al.Purification and unique properties of mammary epithelial stem cells[J].Nature,2006,439(7079):993~997.
26 Sun P,Yuan Y,Li A,et al.Cytokeratin expression during mouse embryonic and early postnatal mammary gland development[J].Histochemistry and Cell Biology,2010,133(2):213~221.
27 Tani H,Morris R J,Kaur P.Enrichment for murine keratinocyte stem cells based on cell surface phenotype[J].Proceedings of the National Academy of Sciences,2000,97(20):10960~10965.
28 Van Keymeulen A,Rocha A S,Ousset M,et al.Distinct stem cells contribute to mammary gland development and maintenance[J].Nature,2011,479(7372):189~193.
29 Wansbury O,Mackay A,Kogata N,et al.Transcriptome analysis of embryonic mammary cells reveals insights into mammary lineage establishment[J].Breast Cancer Res,2011,13(4):R79.
30 Welm B E,Tepera S B,Venezia T,et al.Sca-1^pos cells in the mouse mammary gland represent an enriched progenitor cell population[J].Developmental Biology,2002,245(1):42~56.
31 Woodward W A,Chen M S,Behbod F,et al.On mammary stem cells[J].Journal of Cell Science,2005,118(16):3585~3594.

[1]	WU Xuan, ZENG Shenming. Research Progress on the Function,Application and Purification Technology in Serum Albumin [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(6): 2265-2275.
[2]	LIU Peng, LI Jingjing, QIAO Yanliang, ZHU Lianqin, ZHU Fenghua. Extraction and Structure Characterization of Scutellaria baicalensis Polysaccharide [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(6): 2518-2530.
[3]	LIU Hongrun, ZHU Siran, FENG Lingli, ZHANG Kun, YAN Gang, WANG Yubin, ZHANG Shuai, JIANG Shan, XU Di, LAN Ganqiu, LIANG Jing. Cloning,Bioinformatics Analysis and Tissue Expression Localization of CDO1 Gene in Large White Pigs [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(4): 1352-1363.
[4]	LI Huawei, GUO Kewei, WANG Xuying, ZHANG Xiaoyu, LU Ziwei, LI Xinfeng, MA Hui, HOU Wenjing. Eukaryotic Expression and Subcellular Localization of Nonstructural Protein 7 of Porcine Reproductive and Respiratory Syndrome Virus [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(3): 1160-1168.
[5]	TANG Jingyu, DU Hanyu, MENG Chunchun, LIU Guangqing. Cloning,Bioinformatics Analysis and Subcellular Localization of Interferon-stimulated Gene 15 in Goats [J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(8): 2843-2854.
[6]	SONG Shiying, GUO Weilu, XIA Xuefeng, ZHANG Xue, BI Zhenwei, ZHANG Xuehan, FAN Baochao, DONG Hailong, LI Bin. Expression and Purification of Porcine IFN-δ5 and Its Effect Analysis Against PEDV Infection [J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(8): 3171-3179.
[7]	DU Wenqi, XIA Liye, LI Guimei, SHAN Hu. Prokaryotic Expression and Purification of Seneca Virus A VP1 Protein [J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(7): 2708-2715.
[8]	LIU Ru, LI Xiaolong, ZHANG Xiaoqian, TIAN Xiaohuan, YU Mei, ZHAO Shuhong, CAO Jianhua. Prokaryotic Expression and Activity Identification of LbCas12a Protein [J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(5): 1621-1629.
[9]	LI Tianxi, DANG Meng, LONG Miao. Identification of an Antagonistic Strain of Aspergillus flavus and Preliminary Analysis of Its Antibacterial Components [J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(5): 1828-1839.
[10]	QIU Runhui, GUAN Feihu, TAO Tingting, LI Jia, ZHAO Tianyi, DENG Xingmei, SHI Chao, SUN Zhihua, ZHANG Hui. Subcellular Localization and Screening of Host Interacting Proteins of Brucella Secreted Protein BPE005 [J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(4): 1438-1448.
[11]	PANG Feng, LONG Qinqin, LIANG Shaobo, CHENG Hongsong, CHENG Zhentao. Bioinformatics Analysis,Eukaryotic Expression and Subcellular Localization of Orf Virus ORFV114 Protein [J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(11): 4150-4158.
[12]	ZHANG Tianai, LI Tingting, TAO Xiaoli, LI Tengfei, LIN Jiafeng, HU Siman, LIU Wenxiu, TONG Wei, LI Yonggang. Prokaryotic Expression of Porcine Epidemic Diarrhea Virus S Protein and Preparation and Identification of Its Polyclonal Antibody [J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(11): 4383-4391.
[13]	ZHANG Xingyan, WU Zhuyue, YI Xianfeng, LAN Xi, ZHU Wen, CHEN Zhonghua, LAN Haien. Study on the Effect of Small-cell Fully-closed Partition Hoggery on the Control and Purification of Pig Epidemic Disease [J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(11): 4438-4446.
[14]	FEI Yaqi, TANG Chi, DENG Liang. Bioinformatics Analysis,Purification and Identification of Alpha-1-acid Glycoprotein in Serum of Donkey [J]. China Animal Husbandry and Veterinary Medicine, 2021, 48(8): 2705-2712.
[15]	YU Jiamin, ZHAO Qian, ZHANG Zhiyan, XU Haiyan, GU Wei. Separation,Purification and Characteristics Analysis of Antibacterial Peptides from Paenibacillus polymyxa [J]. China Animal Husbandry and Veterinary Medicine, 2021, 48(8): 2830-2837.

Study Progress of Mammary Stem Cells in Animal

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments