青天葵提取物对小鼠急性肺损伤的保护作用

Abstract

Abstract: To explore the protective effects of the ethyl acetate extract from leaf of Ford Nervilia on acute lung injury(ALI),Kunming rats were randomly divided into three groups of the control group,the endotoxin group and the leaf of Ford Nervilia injection group,and each group was used the method of the abdominal cavity injection of endotoxin ALI modle.The expression of MDA and SOD in lung homogenate were examined meanwhile examining lung wet/dry weight ratio(W/D),pathological section, and the histopathological change of lung tissure were observed. The results showed that the ethyl acetate extract could significantly reduce the morphological changes of lung tissure. The MDA and SOD in lung homogenate were significant differences compared with the control group. Comfirmed that the ethyl acetate extract from leaf of Ford Nervilia had a protective effects to the ALI.

Key words: leaf of Ford Nervilia; ethyl acetate extract; ALI; protective effects

CLC Number:

S853.7

SHANG Si-wei, LIN Hong-jin, GUAN Hong-yu. The Protective Effects of the Extract from Leaf of Ford Nervilia on Acute Lung Injury of Rats[J]. , 2012, 39(12): 222-224.

References

1 刘红微,赵丽芹,张田田,等.土庄绣线菊水浸液对小鼠急性酒精肝损伤保护作用的研究[J].中国畜牧兽医, 2012, 39(4): 166~168.
2 李娟,柴小青,陈昆洲.氟比洛酚酯对内毒素急性肺损伤中性粒细胞肺内聚集与氧自由基损伤的抑制作用[J].临床麻醉学杂志,2010,26(11):966~968.
3 何小飞,杨勤,谢汝佳,等.丹芍化纤对大鼠肺纤维化模型肺组织匀浆中SOD活性和MDA含量的影响[J].黔南民族医转学报,2010,23(3):161~164.
4 张德信,孙秀珍,刘昀,等.油酸致家兔急性肺损伤早期氧自由基的变化与肺损伤的关系[J].临床肺科杂志,2009,14(5):588~589.
5 杨洋.柚皮黄酮抗氧化机理及其含量的测定[J].广西轻工业,2002,1:36~38.
6 周燕园,甄汉深,袁叶飞,等.HPLC法测定青天葵中鼠李柠檬素和鼠李秦素[J].中草药,2009,40(7):1152~1154.
7 高晓玲.氧自由基在急性肺损伤发病中的作用[J].国外医学(呼吸系统分册),2002,22(6):310~315.
8 袁叶飞.青天葵化学成分及其抗肿瘤作用的研究.成都:成都中医药大学,2006.
9 梅全喜.青天葵的化学成分药理作用与临床应用研究进展[J].中华中医药学刊,2008,26(10):2239~2241.
10 彭宇明,安立新,王保国.多次给予羟乙基淀粉或高渗氯化钠溶液对实验性脑出血大鼠局部氧化损伤和炎性反应的影响[J].中国康复理论与实践,2009,15(9):838~840.
11 甄汉深,周燕园,袁叶飞,等.青天葵乙酸乙酯部位化学成分研究[J].中药材,2007,30(8):942~945.
12 甄汉深,丘琴,莫缘恒,等.青天葵石油醚部位化学成分研究[J].中药材,2010,33(5):717~719.
13 Gosain A,Gamelli R L.A primer in cytokines[J].Burn Care Rehabil,2005,26(2):7~12.
14 MacLaren R,Stringer K A. Emerging role of anticoagulants and fibrinolytics in the treatment of acute respiratory distress syndrome[J].Pharmacotherapy,2007,27(6):860~873.
15 Shbauqh D G,Biqelow D B,Petty T L,et al.Acute respiratory distress in adults[J].Lancet,1967,7511(2):319~323.

[1]	ZHONG Yueyun, YANG Shuzhan, CHEN Feiyue, LU Zhier, LI Bingxin, LI Wanyan, TIAN Yunbo, HUANG Yunmao, XU Danning, CAO Nan. Effects of LPS on Apoptosis of Goose Embryo-derived Hepatocytes ROS/p38/MAPK Signaling Pathway [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(6): 2224-2232.
[2]	DU Yuanjun, DUAN Guochao, LIU Wei, LI Dapeng, HAN Haixia, LEI Qiuxia, ZHOU Yan, LIU Jie, WANG Jie, CAO Dingguo, LI Fuwei, CHEN Fu. Effect of Translucent on Egg Quality and Its Relationship with Intestinal Function of Laying Hen [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(6): 2305-2311.
[3]	YANG Qinglin, WU Hao, LIU Jiayan, FU Yuxin, ZHOU Shuaishuai, LU Han, DING Manyi, LI Yao. Study of Quercetin Feed Additives on Prolonging Storage Time of Eggs [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(6): 2342-2353.
[4]	XU Yuanyuan, ZHENG Haiying, YANG Chunyan, DENG Tingxian, HUANG Chenqian, FENG Chao, LU Xingrong, DUAN Anqin, MO Xia, MA Xiaoya, SHANG Jianghua. Effects of Inhibition of BMP/Smad Signaling Pathway on the Growth and Steroid Hormone Synthesis of Buffalo Ovarian Granulosa Cells [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(6): 2354-2362.
[5]	LI Can, LI Chuchu, ZENG Wei, ZHANG Ning, JI Chunxiao, CHEN Tao. Recombinant Expression and Function Study of RegⅢγ Protein in Porcine [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(6): 2414-2426.
[6]	NIU Yeyu, SHEN Qi, BAI Yong, SUN Panpan, SUN Na, YIN Wei, FAN Kuohai, LI Hongquan, SUN Yaogui. Anti-inflammatory and Antioxidative Effects of Extracts of Physalis Calyx seu Fructus Based on Ulcerative Colitis Model [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(6): 2531-2539.
[7]	SONG Chenglei, ZHANG Zhe, WEI Yilin, YANG Songbai, DOU Yaqing, LI Chenlei, LIU Yingke, LI Xinjian, YANG Feng, LI Xiuling, WANG Kejun, QIAO Ruimin, HAN Xuelei. Effects of Different Breeds,Seasons and Month Ages on Semen Quality of Boars [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(5): 1938-1946.
[8]	YU Xingang, YUAN Kaijian, MU Xuanru, WANG Hongcai, QI Nanshan, ZHANG Haoji. Research Progress on the Formation of Cyst Wall and Cyst Wall Proteins of Giardia [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(5): 2061-2068.
[9]	LIU Hongrun, ZHU Siran, FENG Lingli, ZHANG Kun, YAN Gang, WANG Yubin, ZHANG Shuai, JIANG Shan, XU Di, LAN Ganqiu, LIANG Jing. Cloning,Bioinformatics Analysis and Tissue Expression Localization of CDO1 Gene in Large White Pigs [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(4): 1352-1363.
[10]	LI Mengyuan, LIU Mengqian, KANG Jiajia, HUANG Ying, DUAN Yong, JIA Junjing, GE Changrong, CAO Weina. Effects of Guanidinoacetic Acid on Meat Quality and Abdominal Fat Deposition in Broilers [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(4): 1385-1394.
[11]	TAN Yuancheng, LUO Hualun, ZHANG Yiyu, YANG Suan, WANG Yingtong, WANG Chunyuan. Polymorphism of MyoG Gene and Its Association with Body Size and Meat Traits in White Feather King Pigeons [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(4): 1461-1471.
[12]	DU Zhaohui, GE Zihao, YOU Junyi, LIU Xiaowei, LIANG Guodong, SUN Shiduo, HU Jianhong, LI Xiao. Effects of Clostridium butyricum and Sodium Butyricum on Reproductive System Injury Induced by High Fat Diet in Male Mice [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(4): 1603-1616.
[13]	XIONG Taidi, JIANG Shouqun, ZHANG Huihua, ZHU Cui. Research Progress on Transportation Stress and Its Mitigation Measures in Poultry [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(3): 977-988.
[14]	LI Huawei, GUO Kewei, WANG Xuying, ZHANG Xiaoyu, LU Ziwei, LI Xinfeng, MA Hui, HOU Wenjing. Eukaryotic Expression and Subcellular Localization of Nonstructural Protein 7 of Porcine Reproductive and Respiratory Syndrome Virus [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(3): 1160-1168.
[15]	LIANG Tian, WANG Mingdi, SUN Peng, ZHU Aichen, ZHAO Qianhui, HUO Shuying. Network Pharmacological Analysis of the Anti-inflammatory Mechanism of Traditional Chinese Medicine Mixture Phellodendron amurense and Acorus calamus [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(3): 1195-1206.

The Protective Effects of the Extract from Leaf of Ford Nervilia on Acute Lung Injury of Rats

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments