Abstract: Through selecting the kinds of adjuvant and its dosage, investigating pharmaceutical technology and stability in granules preparation procedure, the assay was aimend to establish a optimum granules preparation technology of traditional Chinese medicine compound ‘Modified Pulsatilla’. Taking quality of soft material as appraisal indice, investigating the quantity ratio between medicine solution and adjuvant, taking appearance, clear degrees, water content, loss rate of granules quality as appraisal indices to study of the dosage of soluble starch, the dosage of α-lactose, the dosage of dextrin and the concentration of HPMC, and at last to establish a optimum granules preparation technology. When the ratio was 5∶1 between medicine solution and adjuvant, the quality of soft material was good. When the adhesive phase was 0.3% HPMC and the ratio was 3∶1∶1 among soluble starch, α-lactose and dextrin, every appraisal indice of granules was best. Through the test, it was proved that the traditional Chinese medicine compound ‘Modified Pulsatilla’ granules could be preparated in the condition of laboratory. The preparation technology was simple and clear, the granules were forming effective, high stability and up to specification which was in the pharmacopeia of China.

Key words: modified pulsatilla; granular formulation; preparation; stability