Abstract: This article contrasted albumin, thyroxine (T₃, T₄), vitamin, glucose, lactic acid, pyruvic acid, Ca and P in the blood serum of the arthritis puerperium dairy cow, to study that the relation blood biochemical indicator’s changes with Joint disease. The result indicated the albumin, T₄, vitamin A, vitamin C, vitamin E, Ca and P were in experimental group notablely lower than control group, globulin-α, lactic acid, pyruvic acid and T₃ were significant higher than control group. It showed that the content of T₄ and vitamin were degraded in arthritis postpartum dairy cow maked the collagen in articular cartilage and proteoglycan reduce,depolymerization increase,to cause the compose of serum protein change; but blood sugar level depressed that it caused lactic acid and pyruvic acid raise, hypoglycemia inhibited composition of vitamin C, Ca and P level depressed. It maybe effect sclerotin metabolism to promote development of arthritis.

Key words: dairy cow; osteoarthritis; hematological biochemistry