疫苗佐剂胞嘧啶-鸟嘌呤寡脱氧核苷酸的研究进展

›› 2011, Vol. 38 ›› Issue (6): 49-52.

• 生理生化 • Previous Articles Next Articles

Progress on Vaccine Adjuvant CpG ODN

WANG Ya-li¹, WANG Zhen-hua², ZENG Xian-yin¹

1. Sichuan Agricultural University,Ya’an 625014,China;2. Chengdu Vocational College of Agricultural Science and Technology, the Branch College of Animal and Veterinary, Wenjiang 611130,China

Received:2010-12-08 Revised:1900-01-01 Online:2011-06-20 Published:2011-06-20

Abstract

Abstract: Synthetic oligodeoxynucleotides (ODN) containing unmethylated CpG motifs mimic the immunostimulatory activity of bacterial DNA. CpG ODN directly stimulate a variety of immunological effects. CpG ODN is used as vaccine adjuvants, where they increase the vaccine-specific immune responses and the mucosal immune responses. Ongoing clinical studies indicate that CpG ODN are safe and well-tolerated when administered as adjuvants to animals.

Key words: CpG oligodeoxynucleotides; adjuvant; system immunity; mucosal immunity

CLC Number:

S852.4

WANG Ya-li;WANG Zhen-hua;ZENG Xian-yin. Progress on Vaccine Adjuvant CpG ODN[J]. , 2011, 38(6): 49-52.

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