›› 2010, Vol. 37 ›› Issue (8): 149-153.

• 疾病防治 • Previous Articles     Next Articles

Curative Effects of Fructus Mume and Semen Ziziphi Spinosae Extracts against IBD

LI Shu-mei1，ZHANG Fa-ming2，LI Ying-chao3，OU Chang-bo1， CHEN Hui1， CHEN Xi1，HE Cheng1   

  1. (1.College of Veterinary Medicine, China Agricultural University, Beijing 100193, China; 2.Beijing Veterinary Biological Products Factory, Beijing 102209, China; 3.Beijing Institute of Veterinary Drug Control, Beijing 100107, China)
  • Received:1900-01-01 Revised:1900-01-01 Online:2010-08-20 Published:2010-08-20

Abstract: To assess the pharmacological effects of compound of Fructus mume and Semen ziziphi spinosae extracts against infectious bursal disease (IBD) in the laboratory. Firstly, the chickens without the attenuated IBD vaccine were inoculated with the IBDV LX strain in order to establish the virus disease model. Secondly,Fructus mume and Semen ziziphi spinosae extracts were formulated according to the previous study. Chickens were administered orally with 400,200 and 100 mg/kg herb extracts.The chickens were administered with astragalus polysaccharide as the control group.All birds were monitored daily and evaluated the efficacy.The results showed that: ①After experimental infection with IBD,average weight gain of the infected chickens was 81.85% in 200 mg/kg group and 48.24% in astragalus polysaccharide group. As for survival rate, the infected chickens were 87.5% and 100% in above group,respectively.Average weight gain was significant difference in 200 mg/kg group as compared to that of astragalus polysaccharide group. No significance was found between two groups. The chicken bursal index was 0.187 and 0.123, respectively in 200 mg/kg group and in astragalus polysaccharide group while the spleen index were 0.361 and 0.286, respectively in above two groups. There was significant difference (P<0.05) between two groups.②In second experiment, the relative weight gain in above mentioned groups were 29.55 and 46.1 while survival rate was 100% and 80%, respectively, which was no significant difference between 200 mg/kg group and astragalus polysaccharide group. The chicken bursal index were 0.22 and 0.25 while spleen index were 0.34 and 0.36, respectively. Statistical analysis showed that no significant difference was found in immune organ index between two mentioned groups (P>0.05). Chickens were orally administered with 200 mg/kg Fructus mume and Semen ziziphi spinosae extract for 5 days, resulting in maximum 80% survival rate against the artificially challenge with IBD. The improvement of immune organ index contributed to the promising pharmacological effects.

Key words: Fructus mume and Semen ziziphi spinosae extract; infectious bursal disease; pharmacological effects; chicken

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