质粒介导喹诺酮类耐药机制研究进展

›› 2010, Vol. 37 ›› Issue (10): 81-86.

• 生物技术 • Previous Articles Next Articles

Development of Plasmid Mediated Quinolone Resistance Genes

ZHU Heng-qian1, PENG Bin2, LIAO Xiao-ping1

(1.Guangdong Provincial Key Laboratory of Veterinary Pharmaceutics Development and Safety Evaluation, College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China;2.Hunan Province Sangzhi Supervising Agencies for Animal Epidemic Prevention, Sangzhi 427100, China)

Received:1900-01-01 Revised:1900-01-01 Online:2010-10-20 Published:2010-10-20
Contact: LIAO Xiao-pi

Abstract

Abstract: Bacterial resistance to quinolone drugs was improved rapidly with the appearance of plasmid-mediated quinolone resistance (PMQR) genes, and which bring about serious threat to clinical therapy. Currently, we know that quinolone resistance genes (qnr) conferred low-level resistance to quinolone drugs, but this low-level resistance may cause the quantity of bacterial overrun of mutant prevention concentration, and which may lead to high-level resistance to quinolones. Therefore, investigations of plasmid mediated drug resistance to quinolones as well as mechanisms of dissemination of resistance genes in molecular level are not only useful to guide clinical therapy, but also help to control the production and dissemination of resistant strains.

Key words: PMQR; resistance; qnr; quinolone

CLC Number:

S859.7

ZHU Heng-qian;PENG Bin;LIAO Xiao-ping. Development of Plasmid Mediated Quinolone Resistance Genes[J]. , 2010, 37(10): 81-86.

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Development of Plasmid Mediated Quinolone Resistance Genes

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