›› 2010, Vol. 37 ›› Issue (1): 208-210.

• 经验交流 • Previous Articles    

Effects of Echinacea Herb P.E on Micronucleus in Mice

ZHAO Dan1, CHEN Xiu-yun2, SUN Yu1, TANG Ren-xiang1, LIU Ren-jie1, BU Shi-jin1   

  1. (1.Veterinary Medicine College, Yangzhou University, Yangzhou 225009, China;2.Medical College, Yangzhou University, Yangzhou 225001, China)
  • Received:1900-01-01 Revised:1900-01-01 Online:2010-01-20 Published:2010-01-20
  • Contact: BU Shi-jin

Abstract: 50 Kunming mice were randomly divided into five groups. Echinacea Herb P.E was orally given at a dose of 2.5, 1.25 and 0.625 g/kg body weight, respectively. The bone-narrow micronucleus test was undertaken according to the routine method. With a method of two times administration at intervals of 30 h,the mice were killed by cervical dislocation 24 h after oral administration, the permillage of micronucleus cells among polychromatic erythrocytes (PCE) were numbered. The result showed that micronucleus test were not significantly different from the control group, and suggested that Echinacea Herb P.E is no genotoxicity.

Key words: Echinacea Herb P.E; mice; micronucleus test

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