›› 2008, Vol. 1 ›› Issue (11): 62-65.

• 生理生化 • Previous Articles     Next Articles

Effect of FootandMouth Disease Virus 146S Antigen on IL-1 Production by Microvascular Endothelial Cells

ZHANG Tao1,3, TIAN Lifang2, ZHANG Shuang1, HU Ge2, ZHANG Tao2, MU Xiang3, TENG Kedao1   

  1. 1.College of Veterinary Medicine, China Agricultural University, Beijing 100193,China; 2.Department of Animal Science and Technology, Beijing Agricultural College, Beijing 102206,China; 3.Beijing Key Laboratory of Veterinary Medicine (Traditional Chinese Medicine and Pharmacology), Beijing 102206,China
  • Received:1900-01-01 Revised:1900-01-01 Online:2008-11-20 Published:2008-11-20

Abstract: IL-1 plays a key regulatory role in the onset of immune and inflammatory responses. To investigate the role of microvascular endothelial cells (MVECs) in the immune responses to footandmouth disease virus (FMDV), the effects of FMDV 146S antigen on IL-1α and IL-1β production by rat myocardium microvascular endothelial cells (RMMVECs) were assayed by ELISA kit. The study showed that RMMVECs constitutively secreted IL-1α and IL-1β in low level, and their production were significantly upregulated by the stimulation of FMDV 146S antigen. The results indicate that MVECs play an important role in regulating the immune response to FMDV antigen by enhanced production of IL-1.

Key words: footandmouth disease virus 146S particle; microvascular endothelial cells; interleukin-1α; interleukin-1β

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