Abstract: Propolis extremely complex chemical composition determines its broad biological actions. Propolis have anti-bacterial, anti-virus and immunological enhancement etal: particles and antigens link with each other into composites (ISCOM) structure with antigen “warehouse” and the role of immune stimulating compounds: although propolis itself has no antigen property, it plays a part as an immune adjuvant in the promotion of antibody generation.the role and synergies between themselves decide propolis is a immunopotentiator. Since the 1960s, its immunological enhancement and its application in vaccine adjuvant are futher researched, and have achieved satisfactory results, which provide some theoretical guidance to the research and development of new vaccines.

Key words: propolis; immunological enhancement; vaccine adjuvant