自噬在奶牛乳腺炎、酮病、脂肪肝中的作用机制研究进展

doi:10.16431/j.cnki.1671-7236.2024.12.010

Abstract

Abstract: Mastitis,ketosis and fatty liver are common diseases in dairy cows that not only severely harm their health but also cause significant economic losses to the dairy industry.Autophagy,a highly conserved process in eukaryotic life,helps clear harmful substances within cells,ensuring homeostasis and playing a crucial role in maintaining organismal health.There are various pathways for activating autophagy,including lysosomal autophagy mediated by AMPK and mTOR signaling pathways,as well as mitophagy mediated by the PINK1/PARK2 pathway.Additionally,autophagy activation is influenced by various nutrients,such as plant extracts,amino acids and vitamins.The authors discussed the mechanisms of autophagy in common diseases such as mastitis,ketosis and fatty liver in dairy cows,and reviewed recent research developments,aiming to provide a scientific basis for clinical interventions in common dairy cow diseases.

Key words: autophagy; dairy cows; mastitis; ketosis; fatty liver

CLC Number:

S852.21

ZHANG Bo, GENG Yang, LI Tianzun, AO Yingnan, LU Yulai, WU Yinga, QI Zhili. Research Progress on the Mechanisms of Autophagy in Mastitis,Ketosis and Fatty Liver in Dairy Cows[J]. China Animal Husbandry and Veterinary Medicine, 2024, 51(12): 5218-5224.

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Research Progress on the Mechanisms of Autophagy in Mastitis,Ketosis and Fatty Liver in Dairy Cows

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