基于网络药理学探讨白龙散治疗鸡腹泻的作用机制

doi:10.16431/j.cnki.1671-7236.2022.03.033

Abstract

Abstract: 【Objective】 The study was aimed to forecast the material basis, action target and pathway of Bailongsan in treating chicken diarrhea by the novel method of network pharmacology.【Method】 All the active ingredients of Pulsatillae Radix, Coptidis Rhizoma and Gentianae Radix et Rhizoma in Bailongsan, and related potential drug targets were collected by TCMSP.The disease targets related to chicken diarrhea were retrieved from GeneCards and OMIM databases.The drug targets were mapped to disease targets by Venny platform, and the intersection targets were uploaded to the STRING database for analysis.PPI networks were constructed and the key targets were obtained, and GO function and KEGG pathway enrichment analysis were performed for the key targets.【Result】 A total of 27 active ingredients, 57 drug targets and 4 207 disease targets were screened.There were 45 intersection targets.The protein interaction network found that 45 proteins including MYC, ESR1, IL-6 and PTGS2 might be the key targets of Bailongsan in treatment of chicken diarrhea.The GO enrichment analysis identified 112 GO items.The enrichment analysis of KEGG pathway identified 22 related signal pathways.【Conclusion】 The Bailongsan might act on the key targets such as JUN, MYC, ESR1 and IL-6 to treat chicken diarrhea by quercetin, kaempferol, and isorhamnetin, etc.And the pathways were involved in cytokine-cytokine receptor interaction, p53 signaling pathway, MAPK signaling pathway and other pathways.

Key words: Bailongsan; chicken diarrhea; network pharmacology

CLC Number:

S853.7

WANG Xiaoying, LI Xiumei, WANG Xiumin, LIU Weiwei, YANG Juan, TIAN Wei, ZHOU Weiwei, DAI Xiaofeng. Study on the Mechanism of Bailongsan in Treatment of Chicken Diarrhea Based on Network Pharmacology[J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(3): 1106-1116.

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Study on the Mechanism of Bailongsan in Treatment of Chicken Diarrhea Based on Network Pharmacology

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