几种常用饲料添加剂对断奶仔猪肠道菌群调控的研究进展

doi:10.16431/j.cnki.1671-7236.2016.11.019

Abstract

Abstract:

In modern pig production,early weaning is a bottleneck problem which are restricting the development of pig industry.It can lead to early weaning syndrome in piglet,such as low appetite,growth inhibition,diarrhea and so on.One of the reasons induced these symptoms is impairment of intestinal mucosal barrier in piglets.The intestinal microflorais is one of the important parts of intestinal mucosal barrier.Therefore,study on the intestinal microflora of weaning piglets and nutritional regulations have been attracted more and more attentions,and it has an important influence on avoiding diarrhea,promoting the healthy growth and improving growth performance.The change of intestinal microflora in weaning piglets and research development of some common feed additives（microecologics,plant polysaccharide,acidulant,microelement,Chinese herbal medicine and plant extracts）for intestinal microflora were reviewed in this paper.

Key words: weaning piglets; intestinal mucosal barrier; microbiota; nutrition regulation

CLC Number:

S816.7

HOU Guan-yu, ZHOU Han-lin, XUN Wen-juan, CAO Ting, SHI Li-guang. Research Advances on Intestinal Microflora Regulationin by Several Feed Additives in Piglets[J]. , 2016, 43(11): 2939-2944.

References

[1] Tan B,Li X G,Kong X,et al.Dietary L-arginine supplementation enhances the immune status in early-weaned piglets[J].Amino Acids,2009,37(2):323-331.
[2] Yin F G,Liu Y L,Yin Y L,et al.Dietary supplementation with astragalus polysaccharide enhances ileal digestibilities and serum concentrations of amino acids in early weaned piglets[J].Amino Acids,2009,37(2):263-270.
[3] Kraehenbuhl J P,Neutra M R.Molecular and cellular basis of immune protection of mucosal surfaces[J].Physiol Rev,1992,72(4):853-879.
[4] Bourlioux P,Koletzko B,Guarner F,et al.The intestine and its microflora are partners for the protection of the host[J].Am J Clin Nutr,2003,78(4):675-683.
[5] Baumgart D C,Dignass A U.Intestinal barrier function[J].Curr Opin Clin Nutr Metab Care,2002,5(6):685-694.
[6] Danielsen M,Hornshoj H,Siggers R H,et al.Effects of bacterial colonization on the porcine intestinal proteome[J].J Proteome Res,2007,6(7):2596-2604.
[7] Suau A,Bonnet R,Sutren M,et al.Direct analysis of genes encoding 16S rRNA from complex communities reveals many novel molecular species within the human gut[J].Appl Environ Microbiol.1999,65(11):4799-4807.
[8] Hooper L V,Macpherson A J. Immune adaptations that maintain homeostasis with the intestinal microbiota[J].Nat Rev Immunol,2010,10(3):159-169.
[9] Shanahan F. Probiotics in perspective[J].Gastroenterology,2010,139(6):1808-1812.
[10] Zoetendal E G,Collier C T,Koike S,et al.Molecular ecological analysis of the gastrointestinalmicrobiota:A review[J].J Nutr,2004,134(2):465-472.
[11] Konstantinov S R,Zhu W Y,Williams B A,et al.Effect of fermentable carbohydrates on piglet faecal bacterial communities as revealed by denaturing gradient gel electrophoresis analysis of 16S ribosomal DNA[J].FEMS Microbiol Ecol,2003,43:225-235.
[12] Pieper R,Janczyk P,Zeyner A,et al. Ecophysiology of the developing total bacterial and Lactobacillus communities in the terminal small intestine of weaning piglets[J].Microbial Ecology,2008,56:474-483.
[13] Castillo M,Martín-Orúe S M,Nofrarías M,et al.Changes in caecal microbiota and mucosal morphology of weaned pigs[J].Vet Microbiol,2007,124(3-4):239-247.
[14] Janczyk P,Pieper R,Smidt H,et al.Changes in the diversity of pig ileal lactobacilli around weaning determined by means of 16S rRNA gene amplification and denaturing gradient gel electrophoresis[J].FEMS Microbiol Ecol,2007,61(1):132-140.
[15] 孙晓磊.苦豆籽粕-两歧双歧杆菌-唾液轧杆菌合生元对早期断奶仔猪生产性能及消化功能影响的研究[D].呼和浩特:内蒙古农业大学,2013.
[16] Guarner F,Schaafsma G J. Probiotics[J].Int J Food Microbiol,1998,39(3):237-238.
[17] Cho J H,Zhao P Y,Kim I H. Probiotics as a dietary additive for pigs:A review[J]. J Animand Vet Adv,2011,10(16):2127-2134.
[18] Jensen H,Grimmer S,Naterstad K,et al. In vitro testing of commercial and potential probiotic lactic acid bacteria[J]. Int J Food Microbiol,2012,153(1/2):216-222.
[19] Suo C,Yin Y,Wang X,et al.Effects of lactobacillus plantarum ZJ316 on pig growth and pork quality[J].BMC Vet Res, 2012,8:89.
[20] 窦茂鑫,吴涛.不同类型益生素对断奶仔猪肠道微生物区系、pH和挥发性盐基氮的影响[J].中国畜牧兽医,2013,40(2):84-87.
[21] Ohashi Y,Tokunaga M,Taketomo N,et al. Stimulation of indigenous lactobacilli by fermented milk prepared with probiotic bacterium,Lactobacillus delbrueckii subsp bulgaricus strain 2038,in the pigs[J]. J Nutr Sci Vitaminol,2007,53(1):82-86.
[22] 倪学勤,曹希亮,曾东,等.猪源约氏乳酸杆菌JJB3和枯草芽孢杆菌JS01仔猪肠道分泌型免疫球蛋白A和菌群的影响[J].动物营养学报,2008,20(3):275-280.
[23] Maynard C L,Elson C O,Hatton R D,et al.Reciprocal interactions of the intestinal microbiota and immune system[J]. Nature,2012,489(7415):231-241.
[24] Kim K H,Ingale S L,Kim J S,et al. Bacteriophage and probiotics both enhance the performance of growing pigs but bacteriophage are more effective[J]. Anim Feed Sci Tech,2014,196:88-95.
[25] Siepert B,Reinhardt N,Kreuzer S,et al.Enterococcus faecium NCIMB 10415 supplementation affects intestinal immune-associated gene expression in post-weaning piglets[J].Vet Immunol Immunopathol,2014,157(1/2):65-77.
[26] 徐子伟.仔猪肠道损伤修复营养调控及其机制和应用[J].动物营养学报,2014,26(10):3033-3045.
[27] Yoon J H,Ingale S L,Kim J S,et al. Effects of dietary supplementation with antimicrobial peptide-P5 on growth performance,apparent total tract digestibility,faecal and intestinal microflora and intestinal morphology of weanling pigs[J].J Sci Food Agric,2013,93(3):587-592.
[28] Xiao H,Tan B E,Wu M M,et al. Effects of composite antimicrobial peptides in weanling piglets challenged with deoxynivalenol:Ⅱ. Intestinal morphology and function[J]. J Anim Sci,2013,91(10):4750-4756.
[29] 卢俊鑫,杨金波,邝哲师,等.猪源性PR39抗菌肽对断奶仔猪生产性能、血清免疫指标和肠道菌群的影响[J].动物营养学报,2014,26(6):1587-1592.
[30] 张继东,王志祥.中草药多糖的免疫调节机制及其应用[J].饲料工业,2006,27(6):1-4.
[31] 侯伟革.黄茂多糖和黄芬贰对断奶仔猪生产性能、血液指标和免疫机能影响的研究[D].保定:河北农业大学,2006.
[32] 韩杰,张飞,边连全.刺五加多糖对免疫应激断奶仔猪免疫器官指数、粪便微生物菌群数量和胃肠道pH的影响[J].动物营养学报,2014,26(8):2314-2319.
[33] 陈清华,贺建华,刘祝英.牛膝多糖对仔猪肠道微生物及小肠勃膜形态的影响[J].湖南农业大学学报(自然科学版),2007,33(6):723-726.
[34] 任芬芬.牛膝多糖对仔猪各肠段微生物多样性影响的研究[D].长沙:湖南农业大学,2012.
[35] 梅绍锋,余冰,鞠翠芳,等.高锌和高铜对断奶仔猪生产性能、消化生理和盲肠微生物数量的影响[J].动物营养学报,2009,21(6):903-909.
[36] 颜新春.有机微量元素螯合物在动物生产中的应用[J].饲料博览,2005,3:46-48.
[37] 邵建华,陆腾甲.复合氨基酸微量元素鳌合物饲料添加剂的应用与开发[J].饲料工业,2000,21(5):41-44.
[38] Veum T L,Carlson M S,Wu C W,et al. Copper proteinate in weanling pig diets for enhancing growth performance and reducing fecal copper excretion compared withcopper sulfate[J].J Anim Sci,2004,82:1062-1070.
[39] 马玉龙,郭彤,许梓荣.载铜蒙脱石对断奶仔猪腹泻、肠道菌群及肠粘膜形态的影响[J].中国兽医学报,2007,27(2):279-283.
[40] 朱叶萌,谢正军,李云涛,等.壳聚糖铜对断奶仔猪生产性能、肠道菌群及黏膜形态的影响[J].中国农业科学,2011,44(2):387-394.
[41] 朱宇旌,王浩然,李方方,等.半胱胺螯合锌对仔猪生长性能、血清生化指标、养分消化率及粪中微生物菌群的影响[J].动物营养学报,2015,27(10):3225-3232.
[42] Canibe N,Højberg O,Højsgaard S,et al. Feed physical form and formic acid addition to the feed affect the gastrointestinal ecology and growth performance of growing pigs[J]. J Anim Sci,2005,83(6):1287-1302.
[43] 林映才,陈建新,蒋宗勇,等.复合酸化剂对早期断奶仔猪生产性能、血清生化指标、肠道形态和微生物区系的影响[J]. 养猪,2001,1:13-16.
[44] 冷向军,王康宁,杨凤,等.酸化剂对早期断奶仔猪胃酸分泌、消化酶活性和肠道微生物的影响[J]. 动物营养学报,2002,14(4):44-48.
[45] 晏家友,贾刚,王康宁,等.缓释复合酸化剂对断奶仔猪消化道酸度及肠道功能的影响[J]. 畜牧兽医学报,2009,40(12):1747-1754.
[46] 钮海华,王勇,马文强,等.包膜丁酸钠对仔猪肠道微生物细菌数量的影响[J].饲料研究,2010,11:34-36.
[47] 曹国文,曾代勤,戴荣国,等.中草药添加剂对断奶猪肠道菌群与生产性能的影响[J].中国兽医科技,2003,33(11):54-58.
[48] 刘合军,印遇龙,孔祥峰.中药复方对早期断奶仔猪肠道微生态的影响[J].江苏农业学报,2008,24(1):53-58.
[49] 韩剑众,胡永金,田允波,等.中药有效成分抽提物体外抑菌试验及对仔猪生长和肠道微生物区系的影响[J].云南农业大学学报,2002,17(1):56-58.
[50] 刘惠,李丽立,张彬,等.中草药多糖对断奶仔猪肠道微生物菌落的影响[J].饲料工业,2007,28(4):12-15.
[51] 朱宇旌,王博,李方方.植物提取物在断奶仔猪饲粮中的应用效果研究[J].养猪,2016,1:9-12.
[52] 吴超. 复方银黄添加剂促进断奶仔猪生长和预防腹泻的机理研究[D].杭州:浙江大学,2009.

Research Advances on Intestinal Microflora Regulationin by Several Feed Additives in Piglets

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments

[1]	LI Mengrui, LI Yongxia, LIN Xiaofeng, HUANG Xiaohang, HUANG Zhijian, YIN Guangwen. Research Progress on the Interaction Mechanism Between Parasites and Gut Microbiota [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(3): 1129-1139.
[2]	YIN Fangfang, QU Rui, YE Mengjun, HOU Meng, MA Xuejun, PENG Qimin, CHEN Weili, LU Yabin, MAI Zhanhai, WANG Jinquan. Effect of Lactobacillus acidophilus on the Intestinal Flora of Horses Before and After Transport [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(2): 543-555.
[3]	QIU Fei, HAN Yixin, WEI Qilin, TANG Xinggang, YUAN Minggui, DONG Bo, XIANG Rong, XU Zhihong. Research Progress of Culturomics Application in Animal Gut Microbes [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(2): 598-605.
[4]	WANG Yuan, WANG Wenwen, AN Xiaoping, QI Jingwei. Effects of Dietary Fermented Soybean Meal Replacement on Growth Performance, Digestive Enzyme,and Microbita Composition in Weaned Piglets [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(1): 115-124.
[5]	LI Zhuojun, CHEN Chunxiang, ZHONG Xiaoju, GAO Jun. Research Progress on Porcine Gut Microbiota Composition, Influencing Factors and Its Effects on Economically Important Traits [J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(7): 2557-2566.
[6]	LI Hongying, HE Qin, HUANG Enfu, LIANG Qi. Effects of Plant Essential Oils on Immune Function, Antioxidant Capacity and Gut Microbiota of Shan Partridge Ducks [J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(7): 2586-2592.
[7]	LUO Shiqi, ZHANG Xiuwen, SU Jianyu, CHEN Longhai, YANG Lin, WANG Wence. Advances on Intestinal Microorganisms in Waterfowl [J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(3): 845-856.
[8]	JIANG Changjin, CHEN Yun, PAN Pengcheng, CHEN Baojian, GUAN Zhihui, LU Huilin, XIE Bingkun, QIN Zhaoxian. Fecal Microflora Structure and Its Correlation with Growth Rate in Finishing Pigs [J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(3): 924-931.
[9]	PENG Weilong, HOSAMELDEEN Mohamed Husien, BO Ruonan, LIU Mingjiang, YANG Haifeng, LI Jingui. Preventive and Therapeutic Effects of Moringa oleifera Leaf Flavonoids on Ulcerative Colitis in Mice [J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(10): 4042-4051.
[10]	YANG Xizi, WU Shusong, HU Ruizhi, YAN Jiahao, YUAN Xupeng, HE Jianhua. Effects of Dietary Supplementation of β-carotene During Late Pregnancy on Milk Composition and Gut Microbiota in Sows [J]. China Animal Husbandry and Veterinary Medicine, 2021, 48(7): 2378-2387.
[11]	TIAN Weilong, LI Yueyue, LYU Dongling, LIU Xiaoxiao, LIANG Liang, CHENG Feng, CHEN Kuirong, MO Jiayuan, GAO Jiuyu, SI Jinglei, FENG Lingli, LAN Ganqiu, LIANG Jing. Changes of Intestinal Microbiome and Its Influencing Factors at Different Growth Stages in Pigs [J]. China Animal Husbandry and Veterinary Medicine, 2021, 48(2): 509-515.
[12]	PENG Qiaoli, QI Qien, ZHOU Guoyong, TANG Min, CHEN Dongling, LIU Shen, ZHANG Huihua. Effects of Fermented Shiitake Residues on Growth Performance, Colonic Volatile Fatty Acids Contents and Microbial Structure in Weaned Piglet [J]. China Animal Husbandry and Veterinary Medicine, 2021, 48(11): 3985-3995.
[13]	LIU Peng, LI Yong, ZHANG Chengxin, CAI Xiaofang, LI Cailian, GUO Yanli. Variations of Rumen Fermentation and Microflora of Hu Lambs Before and After Early Weaning [J]. China Animal Husbandry and Veterinary Medicine, 2021, 48(1): 144-153.
[14]	ZHANG Zijing, ZHU Xiaoting, LYU Shijie, JIN Lei, XU Jiawei, HUANG Yongzhen, LI Zhiming, WANG Xianwei, YU Xiang, YANG Shang, LI Jing, WANG Eryao, XU Zhaoxue, SHI Qiaoting. Study on the Structure and Function of Fecal Microbiome Between Diarrhea and Healthy Calves [J]. China Animal Husbandry and Veterinary Medicine, 2020, 47(9): 2779-2788.
[15]	LI Xiaotong, YANG Kai, ZHANG Ruiyang, CONG Yuyan. Research Progress of Rumen Development and Its Regulation Mechanism of Ruminants [J]. China Animal Husbandry and Veterinary Medicine, 2020, 47(7): 2055-2062.