头孢洛宁的药理作用及其在奶牛乳房炎防治中应用的研究进展

doi:10.16431/j.cnki.1671-7236.2016.10.034

Abstract

Abstract:

Cephalonium is a second generation cephalosporin.It is effective to prevent and treat mastitis during dry period.It has a broad antibacterial spectrum,strong bactericidal activity,less allergic reactions and low toxicity,and so on,especially showing a good antibacterial activity to Staphylococcus aureus and Streptococus.In this paper,the physical and chemical properties,pharmacokinetic,pharmacology and toxicology,residue and withdrawal periods,application in the prevention and treatment of mastitis in dairy cows,and the prospect of the development of cephalonium were investigated and reviewed.

Key words: cephalonium; mastitis; efficacy; dry period; residue; clinical application

CLC Number:

S859.79

HUA Wei-yi, LIU Yi-ming, XU Fei, LI Xiu-bo. Research Progress on Pharmacological Action of Cephalonium and Its Application in Prevention and Treatment of Mastitis in Dairy Cow[J]. , 2016, 43(10): 2742-2747.

References

[1] 罗文有.奶牛"四大疾病"与犊牛"三大多发病"[J].养殖技术顾问,2013,4:86.
[2] 李帅鹏,郭春娜,孟蕾,等.高效液相色谱-串联质谱法检测牛奶中头孢洛宁残留[J].色谱,2014,32(5):519-523.
[3] 李江红,石克金,陈林.头孢洛宁的合成[A].第十二届全国抗生素学术会议论文集[C].成都:中国抗生素杂志社,2013.
[4] 于海军.β-内酰胺类抗生素作用机制及头孢菌素发展[J].石家庄职业技术学院学报,2009,21(2):12-16.
[5] 张奥博.苄星头孢匹林和头孢洛宁在牛奶中残留检测方法及其乳房灌注剂弃奶期研究[D].扬州:扬州大学,2013.
[6] 易林高,李佳,林洁,等.头孢菌素类抗生素的特点及临床应用[J].海峡药学,2010,22(3):159-161.
[7] 李维静.头孢洛宁乳房灌注剂防治干乳期乳腺炎的药效学及残留消除研究[D].扬州:扬州大学,2014.
[8] Moroni P,Pisoni G,Antonini M,et al.Short communication:Antimicrobial drug susceptibility of Staphylococcus aureus from subclinical bovine mastitis in Italy[J].J Dairy Sci, 2006,89(8):2973-2976.
[9] Owens W E,Nickerson S C,Boddie R L,et al.Prevalence of mastitis in dairy heifers and effectiveness of antibiotic therapy[J].J Dairy Sci,2001,84(4):814-817.
[10] Bradley A J,Breen J E,Payne B,et al.The use of a cephalonium containing dry cow therapy and an internal teat sealant,both alone and in combination[J].J Dairy Sci,2010,93(4):1566-1577.
[11] Shephard R W,Burman S,Marcun P.A comparative field trial of cephalonium and cloxacillin for dry cow therapy for mastitis in Australian dairy cows[J].Aust Vet J,2004,82(10):624-629.
[12] Newton H T,Green M J,Benchaoui H,et al.Comparison of the efficacy of cloxacillin alone and cloxacillin combined with an internal teat sealant for dry-cow therapy[J].Vet Rec,2008,162(21):678-684.
[13] Moroni P,Vellere F,Antonini M,et al.Antibiotic susceptibility of coagulase-negative Staphylococci isolated from goats' milk[J].Int J Antimicrob Agents,2004,23(6):637-640.
[14] Moroni P,Pisoni G,Antonini M,et al.Subclinical mastitis and antimicrobial susceptibility of Staphylococcuscaprae and Staphylococcus epidermidis isolated from two Italian goat herds[J].J Dairy Sci,2005,88(5):1694-1704.
[15] Chart R J.Corynebacterium ulcerans in humans and cattle in North Devon[J].J Hyg (Lond),1984,92(2):161-164.
[16] Committee for Veterinary Medicinal Products.Cefalonium——Summary report(2)[R].2002.
[17] 刘芳.奶牛乳腺炎及其防治[J].中国畜牧兽医文摘,2015,31(8):167-168.
[18] 引兄.奶牛乳腺炎的病因及其防治[J].中国畜牧兽医文摘,2015,31(8):171.
[19] 王小平.奶牛乳腺炎的防治[J].中国畜牧兽医文摘,2015,31(12):162.
[20] Zhang L,Li Y,Bao H,et al.Population structure and antimicrobial profile of Staphylococcus aureus strains associated with bovine mastitis in China[J].MicrobPathog,2016,97:103-109.
[21] Woolford M W,Williamson J H,Day A M,et al.The prophylactic effect of a teat sealer on bovine mastitis during the dry period and the following lactation[J]. N Z Vet J,1998,46(1):12-19.
[22] Rabiee A R,Lean I J.The effect of internal teat sealant products (Teatseal and Orbeseal) on intramammary infection,clinical mastitis,and somatic cell counts in lactating dairy cows:A meta-analysis[J].J Dairy Sci,2013,96(11):6915-6931.
[23] Nickerson S C.Control of heifer mastitis:Antimicrobial treatment——An overview[J].Vet Microbiol,2009,134(1-2):128-135.
[24] Parkinson T J,Vermunt J J,Merrall M.Comparative efficacy of three dry-cow antibiotic formulations in springcalving New Zealand dairy cows[J].N Z Vet J,2000,48(5):129-135.
[25] McDougall S.A randomised,non-inferiority trial of a new cephalonium dry-cow therapy[J].N Z Vet J,2010,58(1):45-58.
[26] Bryan M A,Heuer C,Emslie F R.The comparative efficacy of two long-acting dry-cow cephalonium products in curing and preventing intramammary infections[J].N Z Vet J,2011,59(4):166-173.
[27] Huxley J N,Greent M J,Green L E,et al.Evaluation of the efficacy of an internal teat sealer during the dry period[J].J Dairy Sci,2002,85(3):551-561.
[28] Ospina P A,Rota N,Locatelli C,et al.Randomized noninferiority field trial comparing 2 first-generationcephalosporin products at dry off in quarters receivingan internal teat sealant in dairy cows[J].J Dairy Sci,2016,99(8):1-13.
[29] Berry E A,Hillerton J E.Effect of an intramammary teat seal and dry cow antibiotic in relation to dry period length on postpartum mastitis[J].J Dairy Sci,2007,90(2):760-765.
[30] Laven R A,Balcomb C C,Tulley W T,et al.Effect of dry period length on the effect of an intramammary teat sealant on therisk of mastitis in cattle treated with antibiotics at drying off[J].N Z Vet J,2014,62(4):214-220.
[31] Bates A J,Chambers G,Laven R A.Comparison of cephalonium alone and in combination with an internal teatsealant for dry cow therapy in seasonally calving dairy cows[J].N Z Vet J,2016,64(2):95-100.
[32] Godden S,Rapnicki P,Stewart S,et al.Effectiveness of an internal teat seal in the prevention of new intramammary infections during the dry and early-lactation periods in dairy cows when used with a dry cow intramammary antibiotic[J].J Dairy Sci,2003,86(12):3899-3911.
[33] Demon D,Ludwig C,Breyne K,et al.The intramammary efficacy of first generation cephalosporins against Staphylococcus aureus mastitis in mice[J].Vet Microbiol,2012,160(1-2):141-150.
[34] 吴家鑫.一种在干奶期用于预防奶牛隐性乳腺炎的缓释乳房灌注剂[P].CN201310087067.9.2013.
[35] 姚志扬.一种由7-氨基头孢烷酸一步法制备头孢洛宁的制备方法[P].CN201310747582.5.2013.
[36] 闫星,刘义明,路永强,等.硫酸头孢喹肟乳房注入剂对泌乳期奶牛的安全性研究[J].中国畜牧兽医,2014,41(11):278-282.
[37] 冯言言,王海挺,郑莉,等.硫酸头孢喹肟乳房注入剂治疗奶牛乳房炎的临床疗效观察[J].中国奶牛,2014,5:28-30.
[38] 张道康,刘义明,路永强,等.硫酸头孢喹肟子宫注入剂对奶牛的安全性研究[J].中国农业科学,2015,48(22):4597-4602.
[39] 刘欣,魏占勇,魏丽娟,等.硫酸头孢喹肟对奶牛子宫炎及乳房炎常见病原菌的体外药敏试验[J].黑龙江畜牧兽医,2016,10:162-164.
[40] 瞿红颖,魏丽娟,刘欣,等.硫酸头孢喹肟子宫注入剂对泌乳期奶牛的安全性研究[J].中国畜牧兽医,2016,43(1):227-234.
[41] 冯言言,陈瑞,郑莉,等.盐酸头孢噻呋乳房注入剂治疗奶牛干乳期乳房炎的临床疗效观察[J].中国奶牛,2014,16:20-23.
[42] 党晓林,祁长川,刘红艳,等.复方盐酸头孢噻呋混悬剂的药代动力学研究[J].中国兽药杂志,2012,46(2):10-15.
[43] 陈瑞,王海挺,张智德,等.头孢噻呋及其在奶牛乳房炎治疗上的应用[J].中国奶牛,2013,19:42-45.
[44] 李帅鹏,黄显会,孔祥凯,等.头孢噻呋在猪组织中残留消除规律[J].畜牧兽医学报,2013,44(8):1311-1316.
[45] Wente N,Zoche-Golob V,Behr M,et al.Susceptibility to cephalosporins of bacteria causing intramammary infections in dairy cows with a high somatic cell count in Germany[J].Prev Vet Med,2016,Epub ahead of print.

Research Progress on Pharmacological Action of Cephalonium and Its Application in Prevention and Treatment of Mastitis in Dairy Cow

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