苦豆子植株不同部位醇提液对大鼠离体小肠运动的影响

doi:10.16431/j.cnki.1671-7236.2016.01.024

Abstract

Abstract: To explore the effect of extract from different parts of Sophora alopecuroides picked in autumn on gastrointestinal motility, alcohol extract of bean, pod, leaf and shoot apex of Sophora alopecuroides at increasing dose(0.5% to 8.0%) were added to Tyrode's solution where rat isolated small intestine were bathed.The motility of small intestine was recorded by biological signal processing system.The results showed that the contract frequency and amplitude were significantly decreased when the concentration of each parts of Sophora alopecuroides reached 2.0% to 4.0% compared with that before treatment(P<0.05) and it was the dose dependent relation ship, but had no significant effect on the contract tension(P>0.05).Moreover, the inhibition effect of bean was the strongest among the four parts.Alcohol extract of bean at a dose of 2.0% inhibited the excitatory effect caused by cholinergic M-agonists, bethanechol, and the inhibition couldn't be reversed.The results concluded that different parts of Sophora alopecuroides could inhibit the contraction of rat small intestine, and the inhibition might happen partly by blocked M-receptor, indicating that Sophora alopecuroides are expected to be used to relieve gastrointestinal over contraction due to some reasons.

Key words: Sophora alopecuroides; small intestine; in vitro; smooth muscle; contractility; rat

CLC Number:

S853.7

ZHANG Dan, SHI Gang, ZHOU Yu-dong, YAN Jing, WANG Li-fang, MENG Kun-jie, GUO Jing, ZHAO Hong-qiong. Effect of Alcohol Extract from Different Parts of Sophora alopecuroides on the Motility of Isolated Rat Small Intestine[J]. , 2016, 43(1): 164-170.

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Effect of Alcohol Extract from Different Parts of Sophora alopecuroides on the Motility of Isolated Rat Small Intestine

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