温度和光照对阿维拉霉素稳定性的影响

doi:10.16431/j.cnki.1671-7236.2015.05.025

Abstract

Abstract: The research was aimed to study the stability of avilamycin with different formulations.The relative contents of avilamycin and two main components were determined by high performance liquid chromatography (HPLC).Temperature and light tests were used to study the change rule of the relative content of avilamycin and two main components, so that the stability of avilamycin could be evaluated.The results showed that the formulation of avilamycin premix and avilamycin active pharmaceutical ingredients (API) were sensitive when stored in the conditions of different temperature and light conditions.And avilamycin API and avilamycin A component were more stable than avilamycin premix and avilamycin B component, respectively.So avilamycin should be stored at blow 20 ℃ and no light sealing, which could effectively improve the stability and quality of the product.

Key words: avilamycin; temperature; light; stability

CLC Number:

S859.7

WANG Xue-zhen, CHEN Min. Effect of Temperature and Light on the Stability of Avilamycin[J]. , 2015, 42(5): 1198-1202.

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Effect of Temperature and Light on the Stability of Avilamycin

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