碳水化合物反应元件结合蛋白的研究进展

摘要/Abstract

摘要： 糖脂代谢是人和动物正常生长发育的能源基础,这将直接影响着动物的脂质性状,因此糖脂代谢目前已经成为培育优质畜禽品种的切入点。近年来,发现碳水化合物反应元件结合蛋白(carbohydrate response element binding protein,ChREBP)在调控动物糖脂代谢中具有重要的作用,特别在糖脂代谢的主要场所——肝脏中对糖脂代谢发挥着关键作用。作者就ChREBP的结构特征、组织分布、葡萄糖应答机制、生物学功能、表达调控等方面作一综述,以期为今后的研究提供理论依据。

关键词: 碳水化合物反应元件; 肝脏脂肪变性; 胰岛素抵抗

Abstract: Glycolipid metabolism is the foundation of the energy sources of normal growth and development in human and animals,directly affects the animal lipid traits,therefore it has become the breakthrough point of cultivating high quality livestock and poultry breed. Carbohydrate response element binding protein(ChREBP) plays an important role in regulation of animal glycolipid metabolism in recent years,especially in major site of glycolipid metabolism-liver.In this review,the author summarised the structure characteristics,tissue distributions,mechanism of glucose-responsive,biological functions,gene expression regulation of ChREBP,and it might provide theoretical basis for following research.

Key words: carbohydrate response element binding protein(ChREBP); liver steatosis; insulin-resistance

中图分类号:

R333.4

唐慧, 潘志雄, 王继文, 易军, 王淮, 易礼胜, 邓由飞, 甘佳, 俄木曲者, 付茂忠. 碳水化合物反应元件结合蛋白的研究进展[J]. , 2013, 40(1): 93-98.

TANG Hui, PAN Zhi-xiong, WANG Ji-wen, YI Jun, WANG Huai, YI Li-sheng, DENG You-fei, GAN Jia, E MU Qu-zhe, FU Mao-zhong. Research Progress on Carbohydrate Response Element Binding Protein[J]. China Animal Husbandry & Veterinary Medicine, 2013, 40(1): 93-98.

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