鸡传染性贫血病疫苗研究进展

doi:10.16431/j.cnki.1671-7236.2025.01.031

摘要/Abstract

摘要： 鸡传染性贫血病(chicken infectious anemia,CIA)是临床上最常见的免疫抑制性传染病之一,尚无特异性治疗方法,严重威胁动物健康和养殖业的经济效益。虽然已有部分地区以活疫苗进行CIA的临床预防,但其安全性问题及病毒培养和生产效率低是制约活疫苗推广应用的主要瓶颈。笔者从引起CIA的鸡传染性贫血病毒(Chicken infectious anemia virus,CIAV)的病原学与流行特征、传统疫苗与新型疫苗激发宿主的免疫应答特征与免疫保护力等方面进行全面分析,剖析现有疫苗的优缺点,结合新型疫苗的理论与技术优势,提出CIA高效疫苗的研发方向,为CIA疫苗的研发提供新的思路和科学依据。

关键词: 鸡传染性贫血病; 鸡传染性贫血病毒(CIAV); 感染与免疫; 疫苗研发

Abstract: Chicken infectious anemia (CIA) is one of the most common immunosuppressive infectious diseases in clinical practice.Currently,there is no specific therapy,which poses a serious threat to animal health and the economic benefits of the poultry industry.Although some areas have used live vaccines for clinical prevention of CIA,safety concerns and the low efficiency of virus cultivation and production are the main bottlenecks restricting the promotion and application of live vaccines.The authors conduct a comprehensive analysis of the etiology and epidemiological characteristics of the Chicken infectious anemia virus (CIAV) that causes CIA,as well as the immune response features and protective power of traditional vaccines and new vaccines in stimulating the host’s immune system.By dissecting the advantages and disadvantages of existing vaccines and integrating the theoretical and technological strengths of new vaccines,the authors propose a research direction for the development of efficient CIA vaccines,and provide new ideas and scientific basis for the development of CIA vaccines.

Key words: chicken infectious anemia; Chicken infectious anemia virus (CIAV); infection and immunity; vaccine development

中图分类号:

S852.4

汪磊, 梁琳, 罗润琪, 梁瑞英, 胡丹丹, 司红彬, 丁家波, 邸文达, 汤新明. 鸡传染性贫血病疫苗研究进展[J]. 中国畜牧兽医, 2025, 52(1): 341-350.

WANG Lei, LIANG Lin, LUO Runqi, LIANG Ruiying, HU Dandan, SI Hongbin, DING Jiabo, DI Wenda, TANG Xinming. Research Advancement in Chicken Infectious Anemia Vaccine[J]. China Animal Husbandry and Veterinary Medicine, 2025, 52(1): 341-350.

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