选择信号分析及其对绵羊功能基因的挖掘进展

doi:10.16431/j.cnki.1671-7236.2023.12.016

中国畜牧兽医 ›› 2023, Vol. 50 ›› Issue (12): 4935-4946.doi: 10.16431/j.cnki.1671-7236.2023.12.016

选择信号分析及其对绵羊功能基因的挖掘进展

张彦威^1,2, 于丽娟², 徐新明³, 阿米妮古丽·阿不来孜², 谢梦婉^1,2, 唐丽苹^1,2, 郑培宇^1,2, 狄江²

1. 新疆农业大学动物科学学院, 乌鲁木齐 830052;
2. 新疆畜牧科学院畜牧研究所, 农业农村部畜禽资源(羊)评价利用重点实验室, 新疆绒毛用羊遗传育种与繁殖实验室, 乌鲁木齐 830011;
3. 新疆畜牧科学院生物技术研究所, 新疆动物生物技术重点实验室, 乌鲁木齐 830011

收稿日期:2023-05-15 出版日期:2023-12-05 发布日期:2023-11-28
作者简介:张彦威,E-mail:original10012@163.com。

Advance on Selection Signal Analysis and Its Exploration for Functional Genes in Sheep

ZHANG Yanwei^1,2, YU Lijuan², XU Xinming³, ABULAIZI Aminiguli², XIE Mengwan^1,2, TANG Liping^1,2, ZHENG Peiyu^1,2, DI Jiang²

1. College of Animal Science, Xinjiang Agricultural University, Urumqi 830052, China;
2. Key Laboratory of Genetics Breeding and Reproduction of Xinjiang Cashmere and Wool Sheep, Key Laboratory of Evaluation and Utilization of Livestock and Poultry Resources (Sheep) of the Ministry of Agriculture and Rural Affairs, Institute of Animal Sciences, Xinjiang Academy of Animal Sciences, Urumqi 830011, China;
3. Key Laboratory of Animal Biotechnology of Xinjiang, Institute of Biotechnology, Xinjiang Academy of Animal Sciences, Urumqi 830011, China

Received:2023-05-15 Online:2023-12-05 Published:2023-11-28
Contact: 新疆自治区重点实验室开放课题(2020D04035);国家重点研发计划课题(2021YFD1200901);天山创新团队计划(2022D14018) E-mail:dijiang69@163.com
Supported by:
The project was supported by the National Key Research and Development Program of China (2019YFC1905301);National Natural Science Foundation of China (22078115,21776108,21690083,22008078).

摘要/Abstract

摘要： 绵羊经过长期自然和人工选择,形成了丰富多样的品种资源,并为人类提供肉、奶、毛、皮等生活物资。选择发生时伴随着选择信号的产生,常见的选择信号有群体分化、基因组多样性下降且存在高频等位基因的区域及被选择区域长范围扩展单倍型纯合等。针对不同类型的选择信号衍生出了相应的分析方法,如基于群体分化分析、基于基因组杂合度分析、基于单倍型和连锁不平衡分析和基于等位基因频率谱分析等。近年来,随着高通量测序技术的发展,研究人员通过对绵羊进行选择信号分析,挖掘出大量与经济性状相关的功能基因,为绵羊分子育种提供了更多的遗传信息。作者对选择信号的分类与检测方法及其对绵羊功能基因的筛选进行了介绍,并对选择信号分析的应用方向和研究前景进行了展望,旨在为选择信号分析在绵羊遗传育种中的应用提供借鉴。

关键词: 绵羊; 选择信号; 功能基因

Abstract: Through long-term natural and artificial selection,sheep have developed a rich and diverse variety of breeds that provide humans with meat,milk,wool,fur and other living items.Selection is accompanied by the generation of selection signals,such as population differentiation,decreased genomic diversity and the presence of high-frequency alleles in regions with long-range extended haplotype purity in selected regions.For different types of selection signals,corresponding analysis methods have been derived,such as population differentiation-based analysis,genomic heterozygosity-based analysis,haplotype and linkage disequilibrium-based analysis,and allele frequency profile-based analysis.In recent years,with the development of high-throughput sequencing technology,researchers have been able to mine a large number of functional genes associated with economic traits by performing selection signal analysis in sheep,providing more genetic information for sheep molecular breeding.The author introduces the classification and further presents the advances in utilizing these methods to screen sheep functional genes,the prospects of application and research are predicated on selection signal analysis,which provides valuable information for further applied research of selection signal analysis in sheep genetic breeding.

Key words: sheep; selection signals; functional genes

中图分类号:

S813.3

张彦威, 于丽娟, 徐新明, 阿米妮古丽·阿不来孜, 谢梦婉, 唐丽苹, 郑培宇, 狄江. 选择信号分析及其对绵羊功能基因的挖掘进展[J]. 中国畜牧兽医, 2023, 50(12): 4935-4946.

ZHANG Yanwei, YU Lijuan, XU Xinming, ABULAIZI Aminiguli, XIE Mengwan, TANG Liping, ZHENG Peiyu, DI Jiang. Advance on Selection Signal Analysis and Its Exploration for Functional Genes in Sheep[J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(12): 4935-4946.

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选择信号分析及其对绵羊功能基因的挖掘进展

Advance on Selection Signal Analysis and Its Exploration for Functional Genes in Sheep

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