转录反式作用催化蛋白－超氧化物歧化酶(TAT-SOD)对神经细胞凋亡的保护作用

摘要/Abstract

摘要： 正常机体存在一套比较完整的氧化－抗氧化平衡系统。病理情况下,该系统失衡向氧化方向进行时,便会给机体造成一系列的损伤,产生大量自由基。转录反式作用催化蛋白(TAT)可介导超氧化物歧化酶(SOD)透过血脑屏障进入细胞,甚至线粒体内对其进行清除,从而对机体发挥抗氧化能力及保护作用,尤其对神经细胞凋亡的保护作用尤为明显。TAT介导外源性大分子物质进入细胞的机制众说纷纭,迄今为止,还没有一个明确的、具有说服力的观点。因此,对TAT介导SOD对神经细胞凋亡的保护作用近几年的研究进展作一简要综述具有十分重要的意义。

关键词: 超氧化物歧化酶; TAT-SOD; 神经细胞凋亡

Abstract: Normally, the body exists a set of relatively complete oxidation-antioxidant balance system. In the pathological conditions, this system imbalances to oxidation direction which can cause a series of damage to the body and produce the large amount of free radicals. TAT can mediate SOD through hemato encephalic barrier into the cells even mitochondria, playing the oxidation resistance and protection, especially to nerve cells. At present, the mechanism of TAT mediates allogenic material into cells has different viewpoints and the viewpoints are not clear and persuasive. So it is very important to summarize the research progress of TAT in recent years which can mediate SOD briefly.

Key words: SOD; TAT-SOD; neuronal apoptosis

中图分类号:

Q939.4

李贺, 郑世民. 转录反式作用催化蛋白－超氧化物歧化酶(TAT-SOD)对神经细胞凋亡的保护作用[J]. , 2012, 39(7): 151-154.

LI He, ZHENG Shi-min. The Research of TAT-SOD Protecting Nerve Cell from Apoptosis[J]. China Animal Husbandry & Veterinary Medicine, 2012, 39(7): 151-154.

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