脂联素及其受体激动剂在禽脂肪性肝病中的应用展望

doi:10.16431/j.cnki.1671-7236.2022.02.036

摘要/Abstract

摘要： 脂联素(adiponectin)是一种能参与调控糖和脂质代谢、能量调节、免疫反应以及抵抗炎症、氧化应激和细胞凋亡等多种生理过程的激素。禽脂肪性肝病是由于禽肝脏中脂肪酸合成与酯化、脂肪酸转运、脂肪酸氧化、脂肪分解和利用等代谢途径发生异常, 导致的脂类代谢紊乱、肝细胞脂肪变性和炎症反应。文章介绍了脂联素及其分子结构, 脂联素受体及其参与的信号通路, 并重点阐述了脂联素对肝脏脂质代谢、炎症、氧化应激、肝细胞凋亡与自噬方面的调节作用及机制, 以及脂联素受体激动剂的生理作用。同时, 结合禽脂肪性肝病的发生发展机制, 对脂联素及其受体激动剂的应用前景进行了展望。文章为预防和治疗禽类乃至其他动物的脂肪性肝病提供了新的思路。

关键词: 脂联素; 脂联素受体激动剂; 肝脏; 禽; 脂肪性肝病

Abstract: Adiponectin is a hormone that can participate in the regulation of glucose and lipid metabolism, energy regulation, immune response, resistance to inflammation, oxidative stress and apoptosis.Avian fatty liver disease is lipid metabolism disorder, hepatocyte steatosis and inflammatory reaction caused by abnormal lipid metabolic pathways such as fatty acid synthesis and esterification, fatty acid transport, fatty acid oxidation, lipolysis and utilization in avian liver.This paper introduces adiponectin and its molecular structure, adiponectin receptor and its involved signal pathways, and focuses on the regulatory role and mechanism of adiponectin on liver lipid metabolism, inflammation, oxidative stress, hepatocyte apoptosis and autophagy, as well as the physiological role of adiponectin receptor agonists.At the same time, combined with the occurrence and development mechanism of avian fatty liver disease, the application prospect of adiponectin and its receptor agonists was prospected.This article provides a new idea for the prevention and treatment of fatty liver disease in poultry and even other animals.

Key words: adiponectin; adiponectin receptor agonists; liver; avian; fatty liver disease

中图分类号:

S852

崔埕瑜, 马贲, 赵佳慧, 赵梓娟, 陈雨, 曹中赞, 栾新红. 脂联素及其受体激动剂在禽脂肪性肝病中的应用展望[J]. 中国畜牧兽医, 2022, 49(2): 738-745.

CUI Chengyu, MA Ben, ZHAO Jiahui, ZHAO Zijuan, CHEN Yu, CAO Zhongzan, LUAN Xinhong. Application Prospect of Adiponectin and Its Receptor Agonists in Avian Fatty Liver Disease[J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(2): 738-745.

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