三维重建和3D打印技术在比格犬肝脏模型构建中的应用

doi:10.16431/j.cnki.1671-7236.2023.05.039

摘要/Abstract

摘要： 【目的】运用三维重建和3D打印技术构建比格犬的肝脏三维模型,为犬的肝脏疾病诊疗和相关手术提供三维数据和形态学依据,同时为实验动物的减量使用及提升动物福利奠定基础。【方法】选取1只8月龄、体重14.5 kg的健康雌性比格犬,全身麻醉后静脉注射碘海醇,通过128层螺旋电子计算机断层扫描(computed tomography,CT)对犬的肝脏进行二维图像数据采集,随后利用IPS软件进行数字化分割和三维重建,并使用Touch Viewer软件对图像进行测量。将重建数据传送至3D打印机,逐个生成门静脉、肝静脉、肝动脉等组织的3D打印模型,经上色、图层优化和拼装处理后,最终获得犬的肝脏3D物理模型。【结果】运用CT增强造影数据构建的肝脏三维重建模型形态逼真、立体感强,可在三维空间内进行任意缩放、角度旋转,并可通过调整阈值进行平面映射,形成各部位的切面或单独显示肝动脉、肝静脉、门静脉以及胆管的走向与分布,便于观察各脉管结构的空间位置,展示复杂的肝脏局部解剖结构。Touch Viewer测量结果显示,肝脏体积为556.14 mL,表面积为600.85 cm²,胆囊体积为12.67 mL,表面积为32.47 cm²。3D打印模型显示各组织血管分布清晰、颜色鲜艳,与数字化三维模型基本一致,获得了较为真实且理想的肝脏模型。【结论】利用三维重建和3D打印技术可成功构建犬的肝脏模型,能直观展示复杂的肝脏三维形态和空间结构,可作为数字化、精准化宠物医疗及兽医解剖学、影像学教学的良好模拟平台和实践工具。

关键词: 犬; 肝脏; CT扫描; 三维重建; 3D打印

Abstract: 【Objective】 Three-dimensional reconstruction and 3D printing techniques were used to construct a three-dimensional model of the liver in Beagle dogs to provide three-dimensional data and morphological basis for the diagnosis,treatment and related surgery of liver diseases in dogs,and at the same time,it laid a foundation for the dose reduction and use of experimental animals and improving animal welfare.【Method】 A female 8-month-old healthy Beagle dog weighing 14.5 kg was intravenously injected with iohexol after general anesthesia,and two-dimensional image data were collected from the liver of the dog by 128-slice spiral computed tomography (CT),followed by digital segmentation and three-dimensional reconstruction using IPS software,and images were measured using the Touch Viewer software.Finally,the reconstructed data were transmitted to a 3D printer to generate 3D printed models of portal vein,hepatic vein,hepatic artery and other tissues one by one,and finally the 3D physical model of the dog liver was obtained after coloring,layer optimization and assembly processing.【Result】 The three-dimensional reconstruction model of the liver constructed by CT enhanced angiography data had realistic shape and strong stereoscopic sense,could be arbitrarily scaled and rotated at an angle in the three-dimensional space,and could be mapped plane by adjusting the threshold to form a section of each site or separately display the direction and distribution of the hepatic artery,hepatic vein,portal vein,and bile duct,which was convenient to observe the spatial location of each vascular structure and display the complex local anatomical structure of the liver.Touch Viewer measurements showed the volume of the liver was 556.14 mL with a surface area of 600.85 cm² and the volume of the gallbladder was 12.67 mL with a surface area of 32.47 cm².The 3D printed model showed that the vascularity of each tissue was clear and bright in color,which was basically consistent with the digital three-dimensional model,and a more real and ideal liver model was obtained.【Conclusion】 Three-dimensional reconstruction and 3D printing technology could successfully construct a canine liver model,which could visually display the complex three-dimensional shape and spatial structure of the liver and could be used as a good simulation platform and practical tool for digital and precise pet medicine as well as veterinary anatomy and imaging teaching.

Key words: dog; liver; CT scan; 3D reconstruction; 3D printing

中图分类号:

S829.2

徐嘉辉, 谢嘉欣, 姜成坤, 张森, 姚华, 张华. 三维重建和3D打印技术在比格犬肝脏模型构建中的应用[J]. 中国畜牧兽医, 2023, 50(5): 2130-2138.

XU Jiahui, XIE Jiaxin, JIANG Chengkun, ZHANG Sen, YAO Hua, ZHANG Hua. Application of Three-dimensional Reconstruction and 3D Printing Technology in Beagle Dog Liver Model Construction[J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(5): 2130-2138.

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