畜禽MHCⅠ分子抗原结合槽研究进展

doi:10.16431/j.cnki.1671-7236.2016.08.021

《中国畜牧兽医》 ›› 2016, Vol. 43 ›› Issue (8): 2072-2080.doi: 10.16431/j.cnki.1671-7236.2016.08.021

畜禽MHCⅠ分子抗原结合槽研究进展

郝福星¹, 居元照², 金红岩³, 封家旺³, 袁维峰⁴

1. 江苏农牧科技职业学院, 泰州 225300;
2. 高邮市农业委员会, 高邮 225600;
3. 西藏职业技术学院, 拉萨 850030;
4. 中国农业科学院北京畜牧兽医研究所, 北京 100193

修回日期:2016-02-23 出版日期:2016-08-20 发布日期:2016-08-23
通讯作者: 封家旺 E-mail:fengjiawang126@126.com
作者简介:郝福星(1982-),男,江苏如皋人,硕士,讲师,主要从事动物医学专业科研与教学工作,E-mail:vethfx@163.com
基金资助:
中国农业科学院科技创新工程（ASTIP-IAS-11）

Research Progress on Livestock and Poultry MHCⅠAntigen Binding Groove

HAO Fu-xing¹, JU Yuan-zhao², JIN Hong-yan³, FENG Jia-wang³, YUAN Wei-feng⁴

1. Jiangsu Animal Husbandry and Veterinary College, Taizhou 225300, China;
2. Gaoyou Agriculture Committee, Gaoyou 225600, China;
3. Tibet Vocational Technical College, Lhasa 850030, China;
4. Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing 100193, China

Revised:2016-02-23 Online:2016-08-20 Published:2016-08-23

摘要/Abstract

摘要：

主要组织相容性复合体Ⅰ（major histocompatibility complex, MHCⅠ）结构的解析可直观地阐释其结合抗原表位的机理，进而有效利用其特异性细胞毒性T淋巴细胞（cytotoxic T lymphocyte, CTL）免疫应答。目前已报道的畜禽MHCⅠ精细结构包括牛（N*01301、N*01801）、猪（SLA-1*0401）和鸡（BF2*2101、BF2*0401、BF2*0201、BF2*1401），以上MHCⅠ复合体结构由α1、α2和α3共3个α链和β₂m组成。其抗原结合槽多肽由A、B、C、D、E、F 6个口袋组成，一般B、F口袋决定了不同MHCⅠ分子结合不同性质的抗原多肽。鉴于同一物种不同的MHCⅠ等位基因及不同物种MHCⅠ基因的序列差异性，使得不同的MHCⅠ分子结合不同性质的抗原多肽片段，此外，不同MHCⅠ分子也可递呈同样的抗原多肽，实现不同MHCⅠ分子的交叉递呈。畜禽MHCⅠ的结构清晰地阐释其递呈抗原多肽的机理，促进了畜禽免疫学和疫苗应用的研究。

关键词: 畜; 禽; MHCⅠ; 抗原结合槽

Abstract:

The determination of major histocompatibility complex (MHC) classⅠcomplex structure can elucidate the antigen-binding mechanism,and then effectively utilize the specific CTL response.Currently,several MHCⅠstructures of the livestock and poultry are reported,containing cattle MHCⅠ allele (N*01301,N*01801),pig (SLA-1*0401) and chicken (BF2*2101,BF2*0401,BF2*0201 and BF2*1401).All above MHCⅠstructures are composed of α1,α2,α3 and β₂m chains;And the antigen groove is consisted of six pockets (A,B,C,D,E and F).Generally speaking,how different MHCⅠ binds miscellaneous peptides depends on the B and F pockets.In addition,the MHCⅠsequences have intraspecific and interspecific differences,so the peptides are various for different MHCⅠmolecules.But,different MHCⅠmolecules also can present same peptide,implementing the peptides of cross-presentation.The determination of animal MHCⅠstructures will promote the immunology and vaccine application research.

Key words: livestock; poultry; MHC Ⅰ; antigen binding groove

中图分类号:

R392.11

郝福星, 居元照, 金红岩, 封家旺, 袁维峰. 畜禽MHCⅠ分子抗原结合槽研究进展[J]. 《中国畜牧兽医》, 2016, 43(8): 2072-2080.

HAO Fu-xing, JU Yuan-zhao, JIN Hong-yan, FENG Jia-wang, YUAN Wei-feng. Research Progress on Livestock and Poultry MHCⅠAntigen Binding Groove[J]. , 2016, 43(8): 2072-2080.

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畜禽MHCⅠ分子抗原结合槽研究进展

Research Progress on Livestock and Poultry MHCⅠAntigen Binding Groove

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