P21基因与哺乳动物器官再生相关性研究进展

中国畜牧兽医

P21基因与哺乳动物器官再生相关性研究进展

郭倩倩¹^，2，王大涛²，褚文辉²，赵海平²，孙红梅²，李春义²

（1.江苏科技大学，江苏镇江 212018；2.中国农业科学院特产研究所，吉林省特种经济动物分子生物学国家重点实验室，吉林长春 130112）

收稿日期:2013-11-12 出版日期:2014-05-20 发布日期:2014-06-25
通讯作者: 李春义，博士，研究员，博士生导师，主要从事鹿茸生长发育机制与鹿茸基因工程学研究。E-mail：lichunyi1959@163.com
作者简介:郭倩倩（1989—），女，山东人，硕士生，研究方向：鹿茸分子生物学。
基金资助:
973前期研究专项（2011CB111500）；吉林省自然科学基金（20101575）。

Research Progress of Relationship between P21 Gene and Mammalian Regeneration

GUO Qian-qian¹^，2, WANG Da-tao², CHU Wen-hui², ZHAO Hai-ping², SUN Hong-mei², LI Chun-yi²

(1. Jiangsu University of Science and Technology, Zhenjiang 212018, China; 2. State Key Laboratory for Molecular Biology of Special Wild Economic Animals, Institute of Special Animal and Plant Sciences, Chinese Academy of Agricultural Sciences, Changchun 130112, China)

Received:2013-11-12 Online:2014-05-20 Published:2014-06-25

摘要/Abstract

摘要： 自然界中很多低等无脊椎动物及有尾目两栖动物都存在组织或附属器官再生现象，而哺乳动物中这种能力却是少见的。近年来随着具有器官再生能力的MRL试验小鼠的发现，越来越多的试验证实哺乳动物也具有器官再生能力，这为临床上的损伤修复和肢体再生带来了新希望。组织、器官的再生离不开细胞增殖，细胞增殖离不开细胞周期，p21蛋白作为细胞周期的重要调控因子，在最新研究中发现，普通试验小鼠敲除P21基因后具有了同MRL试验小鼠一样的器官再生能力，确定了p21蛋白与再生有着密切联系。文章对P21基因与哺乳动物再生的关系作一综述。

关键词:

再生; mso-bidi-font-family: 宋体" lang="EN-US">P21基因; 哺乳动物; MRL

Abstract: Animals’capability of regenerating multiple tissue types, organs, and appendages after injury are common among invertebrates and urodele amphibians, but notably such regenerative capacity is rare in mammals. Recently, accumulating evidence has proved that mammals may also have regenerative property with the discovery of MRL mouse, and it brings new hope for clinical therapies. The regeneration of appendages depends on cells proliferation, at the same time, cells proliferation depends on cell cycle, so as one of the cell cycle regulatory proteins, we found the deletion of P21 gene could actually result in full MRL epimorphic regeneration phenotype in a new study, providing a firm link between p21 protein and tissue regeneration. This article reviewed the fields of tissue regeneration and p21 protein, and introduced the relationship between tissue regeneration and p21 protein.

Key words: font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-bidi-font-size: 12.0pt; mso-font-kerning: 1.0pt; mso-ansi-language: EN-US; mso-fareast-language: ZH-CN; mso-bidi-language: AR-SA" lang="EN-US">regeneration; font-size: 10.5pt; mso-bidi-font-family: 宋体; mso-bidi-font-size: 12.0pt; mso-font-kerning: 1.0pt; mso-ansi-language: EN-US; mso-fareast-language: ZH-CN; mso-bidi-language: AR-SA" lang="EN-US">Pfont-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-bidi-font-size: 12.0pt; mso-font-kerning: 1.0pt; mso-ansi-language: EN-US; mso-fareast-language: ZH-CN; mso-bidi-language: AR-SA" lang="EN-US">21 gene; mammals; MRL

郭倩倩，王大涛，褚文辉，赵海平，孙红梅，李春义. P21基因与哺乳动物器官再生相关性研究进展[J]. 中国畜牧兽医.

GUO Qian-qian, WANG Da-tao, CHU Wen-hui, ZHAO Hai-ping, SUN Hong-mei, LI Chun-yi. Research Progress of Relationship between P21 Gene and Mammalian Regeneration[J]. .

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