哺乳动物肠道干细胞与Wnt信号通路研究进展

›› 2013, Vol. 40 ›› Issue (11): 121-125.

哺乳动物肠道干细胞与Wnt信号通路研究进展

张庆东¹, 张成娟², 戴晔³

1. 农业规划设计研究院设施农业研究所, 北京 100125;
2. 山东省安丘市人民医院, 山东安丘 052164;
3. 中国农业科学院北京畜牧兽医研究所, 北京 100193

修回日期:2013-08-23 出版日期:2013-11-20 发布日期:2013-12-19
作者简介:张庆东(1978-),男,江西人,硕士,工程师,研究方向:畜牧工程。
基金资助:
公益性行业(农业)科研专项:现代农业产业工程集成技术与模式研究(200903009)。

Progress on Wnt Pathway in Mammalian Intestinal Stem Cells

ZHANG Qing-dong¹, ZHANG Cheng-juan², DAI Ye³

1. Institute of Facility Agriculture, Chinese Academy of Agricultural Engineering, Beijing 100125, China;
2. Shandong Province Anqiu City People's Hospital, Anqiu 052164, China;
3. Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing 100193, China

Revised:2013-08-23 Online:2013-11-20 Published:2013-12-19

摘要/Abstract

摘要： 肠道干细胞(intestinal stem cells,ISCs)是位于胃肠道的一类具有持续增殖分化能力的细胞;Wnt信号通路是最早发现于果蝇体内的与胚胎发育和癌症发生相关的蛋白质作用网络,对维持肠内稳态具有多层次的调节作用。作者概述了肠道干细胞的研究进展和Wnt信号通路的主要作用,了解了肠道干细胞参与病理性炎性的过程,进而揭示了发育不良和慢性炎症导致癌症的分子机理。

关键词: 哺乳动物; 肠道干细胞; Wnt信号通路

Abstract: Intestinal stem cells (ISCs), a kind of cells which located in the gastrointestinal tract have ability of continuous proliferation and differentiation. Wnt signaling pathway is an embryonic development and cancer-related protein networks which first discovered in Drosophila, the pathway maintains the intestines in a multi-level regulation of the steady state. This article outlines research progress in the field of intestinal stem cells, the function of Wnt signaling pathway, understand intestinal stem cells involved in the pathological inflammatory process, then reveal dysplasia and the molecular mechanisms of chronic inflammation which leads to cancer.

Key words: mammalian; intestinal stem cells; Wnt signaling pathway

中图分类号:

张庆东, 张成娟, 戴晔. 哺乳动物肠道干细胞与Wnt信号通路研究进展[J]. , 2013, 40(11): 121-125.

ZHANG Qing-dong, ZHANG Cheng-juan, DAI Ye. Progress on Wnt Pathway in Mammalian Intestinal Stem Cells[J]. , 2013, 40(11): 121-125.

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