[1] STOB M,BALDWIN R S,TUITE J,et al.Isolation of an anabolic,uterotrophic compound from corn infected with Gibberella zeae[J].Nature,1962,196:1318. [2] BENNETT J W,KLICH M.Mycotoxins[J].Clinical Microbiology Reviews,2003,16(3):497-516. [3] SHIER W T,SHIER A C,XIE W,et al.Structure-activity relationships for human estrogenic activity in zearalenone mycotoxins[J].Toxicon,2001,39(9):1435-1438. [4] MARIN S,RAMOS A J,CANO-SANCHO G,et al.Mycotoxins:Occurrence,toxicology,and exposure assessment[J].Food and Chemical Toxicology,2013,60:218-237. [5] RICE L G,ROSS P F.Methods for detection and quantitation of fumonisins in corn,cereal products and animal excreta[J].Journal of Food Protection,1994,57(6):536-540. [6] 张勇,杨玉林,齐莎日娜,等.2021年国内饲料和饲料原料中霉菌毒素污染状况调查[J].饲料工业,2022,43(15):55-58. ZHANG Y,YANG Y L,QISHA R N,et al.A survey on the mycotoxin contamination of domestic feed and raw materials in 2021[J].Feed Industry Magazine,2022,43(15):55-58.(in Chinese) [7] HUSSEIN H M,BAXTER M,ANDREW I G,et al.Mycotoxin production by Fusarium species isolated from New Zealand maize fields[J].Mycopathologia,1991,113(1):35-40. [8] ZINEDINE A,SORIANO J M,MOLTO J C,et al.Review on the toxicity,occurrence,metabolism,detoxification,regulations and intake of zearalenone:An oestrogenic mycotoxin[J].Food and Chemical Toxicology,2007,45(1):1-18. [9] KUIPER-GOODMAN T,SCOTT P M,WATANABE H.Risk assessment of the mycotoxin zearalenone[J].Regulatory Toxicology and Pharmacology,1987,7(3):253-306. [10] KNUTSEN H K,ALEXANDER J,BARREGARD L,et al.Risks for animal health related to the presence of zearalenone and its modified forms in feed[J].EFSA Journal,2017,15(7):e4851. [11] BURANATRAGOOL K,POAPOLATHEP S,ISARIYODOM S,et al.Dispositions and tissue residue of zearalenone and its metabolites alpha-zearalenol and beta-zearalenol in broilers[J]. Toxicology Reports,2015,2:351-356. [12] DAILEY R E,REESE R E,BROUWER E A.Metabolism of[14C]zearalenone in laying hens[J].Journal of Agricultural and Food Chemistry,1980,28(2):286-291. [13] AKSEL B,GERD H G B,KRISTIAN I,et al.Placental transfer of the estrogenic mycotoxin zearalenone in rats[J].Reproductive Toxicology,2001,15(5):545-550. [14] DANICKE S,SWIECH E,BURACZEWSKA L,et al.Kinetics and metabolism of zearalenone in young female pigs[J].Journal of Animal Physiology and Animal Nutrition,2005,89(7-8):268-276. [15] WANG D F,ZHOU H L,HOU G Y,et al.Soybean isoflavone reduces the residue of zearalenone in the muscle and liver of prepubertal gilts[J].Animal,2013,7(4):699-703. [16] BIEHL M L,PRELUSKY D B,KORITZ G D,et al.Biliary excretion and enterohepatic cycling of zearalenone in immature pigs[J].Academic Press,1993,121(1):152-159. [17] SHIN B S,HONG S H,BULITTA J B.Disposition,oral bioavailability,and tissue distribution of zearalenone in rats at various dose levels[J].Journal of Toxicology and Environmental Health,Part A,2009,72(21/22):1406-1411. [18] FITZPATRICK D W,PICKEN C A,MURPHY L C,et al.Measurement of the relative binding affinity of zearalenone,alpha-zearalenol and beta-zearalenol for uterine and oviduct estrogen receptors in swine,rats and chickens:An indicator of estrogenic potencies[J].Comparative Biochemistry and Physiology,Part C,1989,94(2):691-694. [19] PFEIFFER E,HILDEBRAND A,MIKULA H,et al.Glucuronidation of zearalenone,zeranol and four metabolites in vitro:Formation of glucuronides by various microsomes and human UDP-glucuronosyltransferase isoforms[J].Molecular Nutrition&Food Research,2010,54(10):1468-1476. [20] POPPENBERGER B,BERTHILLER F,BACHMANN H,et al.Heterologous expression of Arabidopsis UDP-glucosyltransferases in Saccharomyces cerevisiae for production of zearalenone-4-O-glucoside[J].Applied and Environmental Microbiology,2006,72(6):4404-4410. [21] ZÖLLNER P,JODLBAUER J,KLEINOVA M,et al.Concentration levels of zearalenone and its metabolites in urine,muscle tissue,and liver samples of pigs fed with mycotoxin-contaminated oats[J].Journal of Agricultural and Food Chemistry,2002,50(9):2494-2501. [22] BRAVIN F,DUCA R C,BALAGUER P,et al.In vitro cytochrome p450 formation of a mono-hydroxylated metabolite of zearalenone exhibiting estrogenic activities:Possible occurrence of this metabolite in vivo[J].International Journal of Molecular Sciences,2009,10(4):1824-1837. [23] PFEIFFER E,HILDEBRAND A,DAMM G,et al.Aromatic hydroxylation is a major metabolic pathway of the mycotoxin zearalenone in vitro[J].Molecular Nutrition&Food Research,2009,53(9):1123-1133. [24] 余增丽,张立实,吴德生.玉米赤霉烯酮对乳腺癌细胞MCF-7增殖和凋亡的影响[J].中华预防医学杂志,2005,39(5):328-331. YU Z L,ZHANG L S,WU D S.Effects of zearalenone on proliferation and aapoptosis in MCF-7 cells[J].Chinese Journal of Preventive Medicine,2005,39(5):328-331.(in Chinese) [25] SU Y,SUN Y,JU D,et al.The detoxification effect of vitamin C on zearalenone toxicity in piglets[J].Ecotoxicology and Environmental Safety,2018,158:284-292. [26] FIORENZA M,MARIA E D A.Zearalenone and reproductive function in farm animals[J].International Journal of Molecular Sciences,2008,9(12):2570-2584. [27] GAO D,CAO X,REN H,et al.Immunotoxicity and uterine transcriptome analysis of the effect of zearalenone (ZEA) in sows during the embryo attachment period[J].Toxicology Letters,2022,357:33-42. [28] 张伟伦,李樵锋,罗颖,等.玉米赤霉烯酮对蛋鸡生产性能、卵巢组织结构及ERα表达的影响[J].中国家禽,2021,43(8):30-35. ZHANG W L,LI Q F,LUO Y,et al.Effects of zearalenone on production performance,ovarian tissue and ERα expression in laying hens[J].China Poultry,2021,43(8):30-35.(in Chinese) [29] YANG J,ZHANG Y,WANG Y,et al.Toxic effects of zearalenone and alpha-zearalenol on the regulation of steroidogenesis and testosterone production in mouse Leydig cells[J].Toxicology in Vitro,2007,21(4):558-565. [30] 董双,何剑斌,张燚,等.玉米赤霉烯酮对雄性小鼠生殖系统的毒性作用[J].畜牧与兽医,2016,48(6):25-29. DONG S,HE J B,ZHANG Y,et al.Toxic effects of zearalenone on male reproductive system in mice[J].Animal Husbandry&Veterinary Medicine,2016,48(6):25-29.(in Chinese) [31] 杨美璐,吴峰洋,刘静慧,等.玉米赤霉烯酮毒性的研究进展[J].饲料研究,2019,42(1):74-77. YANG M L,WU F Y,LIU J H,et al.Advances on research of zearalenone toxicity[J].Feed Research,2019,42(1):74-77.(in Chinese) [32] MAAROUFI K,CHEKIR L,CREPPY E E,et al.Zearalenone induces modifications of haematological and biochemical parameters in rats[J].Toxicon,1996,34(5):535-540. [33] 韩建鑫,何剑斌,高锋,等.原花青素对玉米赤霉烯酮致小鼠肝脏、肾脏氧化损伤的保护作用[J].中国畜牧兽医,2016,43(2):402-406. HAN J X,HE J B,GAO F,et al.Protective effects of proanthocyanidins on the liver and kidney oxidative damage induced by zearalenone in mice[J].China Animal Husbandry&Veterinary Medicine,2016,43(2):402-406.(in Chinese) [34] REDDY K E,SONG J,LEE H J,et al.Effects of high levels of deoxynivalenol and zearalenone on growth performance,and hematological and immunological parameters in pigs[J].Toxins (Basel),2018,10(3):114. [35] 姜淑贞,孙华,黄丽波,等.不同水平玉米赤霉烯酮对断奶仔猪血清代谢产物和肝肾组织病理学影响[J].中国农业科学,2014,47(18):3708-3715. JIANG S Z,SUN H,HUANG L B,et al.Effects of zearalenone contaminated diets on serum metabolite and histopathology of liver and kidney in weaned piglets[J].Scientia Agricultura Sinica,2014,47(18):3708-3715.(in Chinese) [36] WANG Y C,DENG J L,XU S W,et al.Effects of zearalenone on IL-2,IL-6,and IFN-gamma mRNA levels in the splenic lymphocytes of chickens[J].The Scientific World Journal,2012,2012:567327. [37] SAMIR A,ZOUHOUR O,JALILA B S,et al.The protective effect of hydrated sodium calcium aluminosilicate against haematological,biochemical and pathological changes induced by zearalenone in mice[J].Toxicon,2006,47(5):567-574. [38] GINA C P,CORNELIA B,MONICA M,et al.Zearalenone mycotoxin affects immune mediators,MAPK signalling molecules,nuclear receptors and genome-wide gene expression in pig spleen[J].PLoS One,2015,10(5):e0127503. [39] 梁梓森,马勇江,刘长永,等.玉米赤霉烯酮对小鼠免疫器官的毒性作用[J].中国兽医科学,2010,40(3):279-283. LIANG Z S,MA Y J,LIU C Y,et al.In vivo toxicity of zearalenone in immune organs of mice[J].Chinese Veterinary Science,2010,40(3):279-283.(in Chinese) [40] 马勇江,许利娜,李玉谷,等.玉米赤霉烯酮对小鼠脾淋巴细胞凋亡的影响[J].家畜生态学报,2009,30(1):52-56. MA Y J,XU L N,LI Y G,et al.Effects of zearalenone on apoptosis of splenic lymphocytes in mice[J].Acta Ecologae Animalis Domastici,2009,30(1):52-56.(in Chinese) [41] 杨立杰,王淑静,杨维仁,等.玉米赤霉烯酮对断奶小母猪生产性能、血清抗氧化功能和免疫功能的影响[J].动物营养学报,2017,29(8):2843-2850. YANG L J,WANG S J,YANG W R,et al.Effects of zearalenone on production performance,serum antioxidant capacity and immune function of weaning gilts[J].Chinese Journal of Animal Nutrition,2017,29(8):2843-2850.(in Chinese) [42] WANG X,JIANG L P,SHI L M,et al.Zearalenone induces NLRP3-dependent pyroptosis via activation of NF-κB modulated by autophagy in INS-1 cells[J].Toxicology,2019,428:152304. [43] MUTHULAKSHMI S,MAHARAJAN K,HABIBI H R,et al.Zearalenone induced embryo and neurotoxicity in zebrafish model (Danio rerio):Role of oxidative stress revealed by a multi biomarker study[J].Chemosphere,2018,198:111-121. [44] OUANES Z,ABID S,AYED I,et al.Induction of micronuclei by zearalenone in Vero monkey kidney cells and in bone marrow cells of mice:Protective effect of vitamin E[J].Mutation Research:International Journal on Mutagenesis,Chromosome Breakage and Related Subjects,2003,538(1/2):63-70. [45] ABID-ESSEFI S,BAUDRIMONT I,HASSEN W,et al.DNA fragmentation,apoptosis and cell cycle arrest induced by zearalenone in cultured DOK,Vero and Caco-2 cells:Prevention by vitamin E[J].Toxicology,2003,192(2-3):237-248. [46] ABID-ESSEFI S,OUANES Z,HASSEN W,et al.Cytotoxicity,inhibition of DNA and protein syntheses and oxidative damage in cultured cells exposed to zearalenone[J].Toxicology in Vitro,2004,18(4):467-474. [47] SO M Y,TIAN Z,PHOON Y S,et al.Gene expression profile and toxic effects in human bronchial epithelial cells exposed to zearalenone[J].PLoS One,2014,9(5):e96404. [48] SADOVSKY Y,DORN C.Function of steroidogenic factor 1 during development and differentiation of the reproductive system[J].Reviews of Reproduction,2000,5(3):136-142. [49] LIU Q,WANG Y,GU J,et al.Zearalenone inhibits testosterone biosynthesis in mouse Leydig cells via the crosstalk of estrogen receptor signaling and orphan nuclear receptor Nur77 expression[J].Toxicology in Vitro,2014,28(4):647-656. [50] LEE S Y,PARK E,KIM S C,et al.ERalpha/E2 signaling suppresses the expression of steroidogenic enzyme genes via cross-talk with orphan nuclear receptor Nur77 in the testes[J].Molecular and Cellular Endocrinology,2012,362(1-2):91-103. [51] AKINGBEMI B T,GE R,ROSENFELD C S,et al.Estrogen receptor-alpha gene deficiency enhances androgen biosynthesis in the mouse Leydig cell[J].Endocrinology,2003,144(1):84-93. [52] DIAZ-RAMOS J,FLORES-FLORES M,AYALA M E,et al.Impaired serotonin communication during juvenile development in rats diminishes adult sperm quality[J].Systems Biology in Reproductive Medicine,64(5):340-347. [53] ZHENG W,FENG N,WANG Y,et al.Effects of zearalenone and its derivatives on the synthesis and secretion of mammalian sex steroid hormones:A review[J].Food and Chemical Toxicology,2019,126:262-276. [54] HE J,WEI C,LI Y Q,et al.Zearalenone and alpha-zearalenol inhibit the synthesis and secretion of pig follicle stimulating hormone via the non-classical estrogen membrane receptor GPR30[J].Molecular and Cellular Endocrinology,2018,461:43-54. [55] MALEKINEJAD H,COLENBRANDER B,FINK-GREMMELS J.Hydroxysteroid dehydrogenases in bovine and porcine granulosa cells convert zearalenone into its hydroxylated metabolites alpha-zearalenol and beta-zearalenol[J].Veterinary Research Communications,2006,30(4):445-453. [56] SHAMILA A,JAMES S F,ANTONIN B,et al.Signal transduction through the Ras/Erk pathway is essential for the mycoestrogen zearalenone-induced cell-cycle progression in MCF-7 cells[J].Molecular Carcinogenesis,2001,30(2):88-98. [57] 包若昱,王冰洁,冯楠楠,等.ERK信号通路对玉米赤霉烯酮诱导大鼠睾丸支持细胞G2期阻滞的影响[J].中国兽医科学,2018,48(12):1594-1600. BAO R Y,WANG B J,FENG N N,et al.Effects of ERK signaling pathway on G2 phase arrest of rat's sertoli cells induced by zearalenone[J].Chinese Veterinary Science,2018,48(12):1594-1600.(in Chinese) [58] WAFA H,IMEN A,AMAIA A O,et al.The role of oxidative stress in zearalenone-mediated toxicity in HepG2 cells:Oxidative DNA damage,gluthatione depletion and stress proteins induction[J].Toxicology,2007,232(3):294-302. [59] FENG Y Q,ZHAO A H,WANG J J,et al.Oxidative stress as a plausible mechanism for zearalenone to induce genome toxicity[J].Gene,2022,829:146511. [60] ALONSO-GARRIDO M,FRANGIAMONE M,FONT G,et al. In vitro blood brain barrier exposure to mycotoxins and carotenoids pumpkin extract alters mitochondrial gene expression and oxidative stress[J].Food and Chemical Toxicology,2021,153:112261. [61] WANG Y,XING C H,CHEN S,et al.Zearalenone exposure impairs organelle function during porcine oocyte meiotic maturation[J].Theriogenology,2022,177:22-28. [62] YU J Y,ZHENG Z H,SON Y O,et al.Mycotoxin zearalenone induces AIF-and ROS-mediated cell death through p53-and MAPK-dependent signaling pathways in RAW264.7 macrophages[J].Toxicology in Vitro,2011,25(8):1654-1663. [63] CHEN F,LI Q,ZHANG Z,et al.Endoplasmic reticulum stress cooperates in zearalenone-induced cell death of RAW264.7 macrophages[J].International Journal of Molecular Sciences,2015,16(8):19780-19795. [64] ZHENG W,WANG B,SI M,et al.Zearalenone altered the cytoskeletal structure via ER stress-autophagy-oxidative stress pathway in mouse TM4 Sertoli cells[J].Scientific Reports,2018,8(1):3320. [65] WU K J,LIU X,FANG M,et al.Zearalenone induces oxidative damage involving Keap1/Nrf2/HO-1 pathway in hepatic L02 cells[J].Molecular&Cellular Toxicology,2014,10(4):451-457. [66] WANG Y L,ZHOU X Q,JIANG W D,et al.Effects of dietary zearalenone on oxidative stress,cell apoptosis,and tight junction in the intestine of Juvenile grass carp (Ctenopharyngodon idella)[J].Toxins (Basel),2019,11(6):333. [67] WU J,LI J,LIU Y,et al.Tannic acid repair of zearalenone-induced damage by regulating the death receptor and mitochondrial apoptosis signaling pathway in mice[J].Environmental Pollution,2021,287:117557. [68] WANG F,YE X,ZHAI D,et al.Curcumin-loaded nanostructured lipid carrier induced apoptosis in human HepG2 cells through activation of the DR5/caspase-mediated extrinsic apoptosis pathway[J].Acta Pharmaceutica,2020,70(2):227-237. [69] 张凯照,胡会,许泽锴,等.玉米赤霉烯酮对鸡胚成纤维细胞的毒性作用[J].畜牧兽医学报,2022,53(5):1615-1625. ZHANG K Z,HU H,XU Z K,et al.Toxicity of zearalenone on chicken embryo fibroblasts[J].Acta Veterinaria et Zootechnica Sinica,2022,53(5):1615-1625.(in Chinese) [70] XU M L,HU J,GUO B P,et al.Exploration of intrinsic and extrinsic apoptotic pathways in zearalenone-treated rat Sertoli cells[J].Environmental Toxicology,2016,31(12):1731-1739. [71] MA L,HAI S,WANG C,et al.Zearalenone induces mitochondria-associated endoplasmic reticulum membranes dysfunction in piglet Sertoli cells based on endoplasmic reticulum stress[J].Ecotoxicology and Environmental Safety,2023,254:114710. [72] 王宗捷,张瑞雪,刘守勤,等.玉米赤霉烯酮诱导山羊子宫内膜基质细胞凋亡的研究[J].畜牧兽医学报,2021,52(2):535-542. WANG Z J,ZHANG R X,LIU S Q,et al.The apoptotic effect of zearalenone on goat endometrial stromal cells[J].Acta Veterinaria et Zootechnica Sinica,2021,52(2):535-542.(in Chinese) [73] 司梦雪,刘利,王玲玲,等.玉米赤霉烯酮对大鼠睾丸支持细胞Fas/FasL凋亡信号通路的影响[J].中国兽医科学,2018,48(2):262-268. SI M X,LIU L,WANG L L,et al.Effects of zearalenone on apoptosis via the Fas/FasL pathway in sertoli cells[J]. Chinese Veterinary Science,2018,48(2):262-268.(in Chinese) [74] CRYNS V,YUAN J.Proteases to die for[J].Genes&Development,1998,12(11):1551-1570. [75] 林嘉意,谢炬,朱越平,等.代谢组学及其在环境毒理学中的应用[J].生物技术进展,2022,12(5):683-689. LIN J Y,XIE J,ZHU Y P,et al.Metabolomics and its application in environmental toxicology[J].Current Biotechnology,2022,12(5):683-689.(in Chinese) |