非编码RNA调控猪肌间脂肪沉积的研究进展

doi:10.16431/j.cnki.1671-7236.2023.10.027

摘要/Abstract

摘要： 肌间脂肪含量与肉品质密切相关,决定着猪肉的风味、多汁性和嫩度等感官指标,因此,提高肌间脂肪沉积量对改善肉品质有重要作用。肌间脂肪沉积是一个复杂的生物学过程,受多种调控因子和成脂相关信号通路的影响,其中非编码RNA(non-coding RNA,ncRNA)对猪肌间脂肪沉积的调控作用引起了研究者的广泛关注。ncRNA是一类不编码蛋白质的RNA分子,在细胞增殖、分化、凋亡等多种生物学过程中发挥着调控作用。近年来研究表明,ncRNA中微小RNA(microRNA,miRNA)、长链非编码RNA(long non-coding RNA,lncRNA)和环状RNA(circular RNA,circRNA)均是肌间脂肪沉积的潜在调节因子,参与调控动物脂肪沉积过程。作者概述了ncRNA的生物学特性,介绍了肌间脂肪细胞的来源,总结了现阶段ncRNA在猪肌间脂肪沉积中的研究进展,以期为猪肉品质改良提供基础数据。

关键词: 非编码RNA; 猪; 肌间脂肪; 肉品质

Abstract: The content of intermuscular fat is closely related to meat quality,which determines sensory indicators such as flavor,juiciness,and tenderness of pork.Therefore,increasing intermuscular fat deposition plays an important role in improving meat quality.Intermuscular fat deposition is a complex biological process influenced by multiple regulatory factors and lipogenesis-related signaling pathways,among which the role of non-coding RNA (ncRNA) has attracted much attention from researchers. ncRNA is a class of RNA molecules that do not encode proteins,and plays a regulatory role in cell proliferation,differentiation,apoptosis and other biological processes.Recent studies have shown that microRNA (miRNA),long non-coding RNA (lncRNA) and circular RNA (circRNA) are potential regulators of intermuscular fat deposition and are involved in the regulation of fat deposition in animals.The authors summarized the biological characteristics of ncRNA,introduced the origin of intermuscular fat cells,and summarized the current research progress of ncRNA in pig intermuscular fat deposition,in order to provide basic data for pork quality improvement.

Key words: non-coding RNA; pig; intermuscular fat; meat quality

中图分类号:

Q752

谢芳, 罗君谊, 陈婷, 习欠云, 张永亮, 孙加节. 非编码RNA调控猪肌间脂肪沉积的研究进展[J]. 中国畜牧兽医, 2023, 50(10): 4133-4140.

XIE Fang, LUO Junyi, CHEN Ting, XI Qianyun, ZHANG Yongliang, SUN Jiajie. Research Progress on Non-coding RNA Regulating Intermuscular Fat Deposition in Pig[J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(10): 4133-4140.

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