中国畜牧兽医 ›› 2022, Vol. 49 ›› Issue (2): 791-799.doi: 10.16431/j.cnki.1671-7236.2022.02.042
• 临床兽医 • 上一篇
田仰清, 汪娅媛, 昂艳芬, 严涵, 刘鑫, 严玉霖
收稿日期:
2021-07-26
出版日期:
2022-02-05
发布日期:
2022-01-27
通讯作者:
严玉霖
E-mail:yanyulin333@163.com
作者简介:
田仰清,E-mail:1814295407@qq.com
基金资助:
TIAN Yangqing, WANG Yayuan, ANG Yanfen, YAN Han, LIU Xin, YAN Yulin
Received:
2021-07-26
Online:
2022-02-05
Published:
2022-01-27
摘要: 造血干细胞(hematopoietic stem cell, HSC)位于造血系统的顶端, 是造血系统中唯一具有多能性和自我更新能力的细胞, 可以分化为各种功能的血细胞, 维持血液系统的建立和动态平衡, 是目前研究最为透彻、临床应用最为成熟的成体干细胞。造血干细胞的这些重要特性, 使得基于造血干细胞在治病机制研究和临床应用中的研究取得了很大进展。以造血干细胞为基础的再生医学治疗是目前治疗恶性血液病和遗传病的首选方法, 如造血干细胞治疗犬白细胞黏附缺陷综合征、犬遗传性贫血、犬淋巴瘤、犬白细胞减少症、犬X连锁严重联合免疫缺陷病等, 但由于白细胞抗原匹配的供体稀缺、可获得的造血干细胞数量有限等原因, 无法满足临床需求, 因此, 如何通过体外培养获得满足临床需要的造血干细胞成为近年来学者们研究的热点问题。作者参照现有研究成果对造血干细胞的来源和体外分离培养、治病机制进行系统的描述, 并对造血干细胞移植治疗遗传性溶血性贫血、白细胞黏附缺陷综合征、淋巴瘤、白细胞减少症、X连锁严重联合免疫缺陷病的临床研究进行综述, 以期为今后将造血干细胞广泛应用于临床治疗提供参考依据。
中图分类号:
田仰清, 汪娅媛, 昂艳芬, 严涵, 刘鑫, 严玉霖. 犬造血干细胞移植的作用机制及应用研究进展[J]. 中国畜牧兽医, 2022, 49(2): 791-799.
TIAN Yangqing, WANG Yayuan, ANG Yanfen, YAN Han, LIU Xin, YAN Yulin. Research Progress on Therapeutic Mechanism and Application of Canine Hematopoietic Stem Cell Transplantation[J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(2): 791-799.
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