[1] SULLIVAN R,LÉGARÉ C,LAMONTAGNE-PROULX J,et al.Revisiting structure/functions of the human epididymis[J].Andrology,2019,7(5):748-757. [2] BASKARAN S,PANNER SELVAM M K,et al.Exosomes of male reproduction[J].Advances in Clinical Chemistry,2020,95:149-163. [3] GERVASI M G,VISCONTI P E.Molecular changes and signaling events occurring in spermatozoa during epididymal maturation[J].Andrology,2017,5(2):204-218. [4] JAMES E R,CARRELL D T,ASTON K I,et al.The role of the epididymis and the contribution of epididymosomes to mammalian reproduction[J].International Journal of Molecular Sciences,2020,21(15):5377. [5] O'FLAHERTY C.Orchestrating the antioxidant defenses in the epididymis[J].Andrology,2019,7(5):662-668. [6] MORIELLI T,O'FLAHERTY C.Oxidative stress impairs function and increases redox protein modifications in human spermatozoa[J].Reproduction,2015,149(1):113-123. [7] BARATI E,NIKZAD H,KARIMIAN M.Oxidative stress and male infertility:Current knowledge of pathophysiology and role of antioxidant therapy in disease management[J].Cellular and Molecular Life Sciences,2020,77(1):93-113. [8] KINO K,SUGIYAMA H.GC——>CG transversion mutation might be caused by 8-oxoguanine oxidation product[J].Nucleic Acids Symposium Series,2000,44:139-140. [9] ZHONG H,YIN H.Role of lipid peroxidation derived 4-hydroxynonenal (4-HNE) in cancer:Focusing on mitochondria[J].Redox Biology,2015,4:193-199. [10] AITKEN R J,DREVET J R.The importance of oxidative stress in determining the functionality of mammalian spermatozoa:A two-edged sword[J].Antioxidants (Basel),2020,9(2):111. [11] BARATI E,NIKZAD H,KARIMIAN M.Oxidative stress and male infertility:Current knowledge of pathophysiology and role of antioxidant therapy in disease management[J].Cellular and Molecular Life Sciences,2020,77(1):93-113. [12] WU P Y,SCARLATA E,O'FLAHERTY C.Long-term adverse effects of oxidative stress on rat epididymis and spermatozoa[J].Antioxidants (Basel),2020,9(2):170. [13] BARROSO G,MORSHEDI M,OEHNINGER S.Analysis of DNA fragmentation,plasma membrane translocation of phosphatidylserine and oxidative stress in human spermatozoa[J].Human Reproduction,2000,15(6):1338-1144. [14] DAS M,AL-HATHAL N,SAN-GABRIEL M,et al.High prevalence of isolated sperm DNA damage in infertile men with advanced paternal age[J].Journal of Assisted Reproduction and Genetics,2013,30(6):843-848. [15] NOBLANC A,KOCER A,CHABORY E,et al.Glutathione peroxidases at work on epididymal spermatozoa:An example of the dual effect of reactive oxygen species on mammalian male fertilizing ability[J].Journal of Andrology,2011,32(6):641-650. [16] RANA M,ROY S C,DIVYASHREE B C.Sperm antioxidant defences decrease during epididymal transit from caput to cauda in parallel with increases in epididymal fluid in the goat (Capra hircus)[J].Reproduction,Fertility,and Development,2017,29(9):1708-1719. [17] O'FLAHERTY C.Orchestrating the antioxidant defenses in the epididymis[J].Andrology,2019,7(5):662-668. [18] PEEKER R,ABRAMSSON L,MARKLUND S L.Superoxide dismutase isoenzymes in human seminal plasma and spermatozoa[J].Molecular Human Reproduction,1997,3(12):1061-1066. [19] AITKEN R J,BUCKINGHAM D W,CARRERAS A,et al.Superoxide dismutase in human sperm suspensions:Relationship with cellular composition,oxidative stress,and sperm function[J].Free Radical Biology and Medicine,1996,21(4):495-504. [20] ZUBKOVA E V,ROBAIRE B.Effect of glutathione depletion on antioxidant enzymes in the epididymis,seminal vesicles,and liver and on spermatozoa motility in the aging Brown Norway rat[J].Biology Reproduction,2004,71(3):1002-1008. [21] NEGRI L,BENAGLIA R,MONTI E,et al.Effect of superoxide dismutase supplementation on sperm DNA fragmentation[J].Archivio Italiano di Urologia,Andrologia,2017,89(3):212-218. [22] JEMEC A,DROBNE D,TISLER T,et al.Biochemical biomarkers in environmental studies——Lessons learnt from enzymes catalase,glutathione S-transferase and cholinesterase in two crustacean species[J].Environmental Science and Pollution Research International,2010,17(3):571-581. [23] GAETANI G F,KIRKMAN H N,MANGERINI R,et al.Importance of catalase in the disposal of hydrogen peroxide within human erythrocytes[J].Blood,1994,84(1):325-330. [24] HOLLAND M K,STOREY B T.Oxygen metabolism of mammalian spermatozoa.Generation of hydrogen peroxide by rabbit epididymal spermatozoa[J].Biochemical Journal,1981,198(2):273-280. [25] ALVAREZ J G,STOREY B T.Lipid peroxidation and the reactions of superoxide and hydrogen peroxide in mouse spermatozoa[J].Biology of Reproduction,1840,30(4):833-841. [26] JEAN-FRANÇOIS B,CHATTERJEE S,MARC-ANDRÉ S,et al.Levels of antioxidant defenses are decreased in bovine spermatozoa after a cycle of freezing and thawing[J].Molecular Reproduction and Development,2000,55(3):282-288. [27] KAR S,DIVYASHREE B C,ROY S C.Temporal leakage of Cu,Zn superoxide dismutase and loss of two low-molecular-weight forms of glutathione peroxidase-1 from buffalo (Bubalus bubalis) sperm after freezing and thawing[J].Theriogenology,2015,83(4):512-519. [28] KOZIOROWSKA-GILUN M,KOZIOROWSKI M,FRASER L,et al.Antioxidant defence system of boar cauda epididymidal spermatozoa and reproductive tract fluids[J].Reproduction in Domestic Animals,2011,46(3):527-533. [29] JEULIN C,SOUFIR J C,WEBER P,et al.Catalase activity in human spermatozoa and seminal plasma[J].Gamete Research,1989,24(2):185-196. [30] TRAMER F,ROCCO F,MICALI F,et al.Antioxidant systems in rat epididymal spermatozoa[J].Biology of Reproduction,1998,59(4):753-758. [31] KUMAR A,YADAV B,SWAIN DK,et al.Dynamics of HSPA1A and redox status in the spermatozoa and fluid from different segments of goat epididymis[J].Cell Stress and Chaperones,2020,25(3):509-517. [32] CHABORY E,DAMON C,LENOIR A,et al.Mammalian glutathione peroxidases control acquisition and maintenance of spermatozoa integrity[J].Journal of Animal Science,2010,88(4):1321-1331. [33] CHABORY E,DAMON C,LENOIR A,et al.Epididymis seleno-independent glutathione peroxidase 5 maintains sperm DNA integrity in mice[J].Journal of Clinical Investigation,2009,119(7):2074-2085. [34] ZUBKOVA EV,ROBAIRE B.Effects of ageing on spermatozoal chromatin and its sensitivity to in vivo and in vitro oxidative challenge in the Brown Norway rat[J].Human Reproduction,2006,21(11):2901-2910. [35] FORESTA C,FLOHÉ L,GAROLLA A,et al.Male fertility is linked to the selenoprotein phospholipid hydroperoxide glutathione peroxidase[J].Biology of Reproduction,2002,67(3):967-971. [36] SCHNEIDER M,FÖRSTER H,BOERSMA A,et al.Mitochondrial glutathione peroxidase 4 disruption causes male infertility[J].FASEB Journal,2009,23(9):3233-3242. [37] CONRAD M,MORENO S G,SINOWATZ F,et al.The nuclear form of phospholipid hydroperoxide glutathione peroxidase is a protein thiol peroxidase contributing to sperm chromatin stability[J].Molecular and Cellular Biology,2005,25(17):7637-7644. [38] DUFAURE J P,LAREYRE J J,SCHWAAB V,et al.Structural organization,chromosomal localization,expression and phylogenetic evaluation of mouse glutathione peroxidase encoding genes[J].Comptes Rendus de l'Académie des Sciences-Series Ⅲ-Sciences de la Vie,1996,319(7):559-568. [39] GHYSELINCK N B,DUFAURE I,LAREYRE J J,et al.Structural organization and regulation of the gene for the androgen-dependent glutathione peroxidase-like protein specific to the mouse epididymis[J].Molecular Endocrinology,1993,7(2):258-272. [40] VILAGRAN I,CASTILLO-MARTÍN M,PRIETO-MARTÍNEZ N,et al.Triosephosphate isomerase (TPI) and epididymal secretory glutathione peroxidase (GPX5) are markers for boar sperm quality[J].Animal Reproduction Science,2016,165:22-30. [41] BOE-HANSEN G B,CHRISTENSEN P,VIBJERG D,et al.Sperm chromatin structure integrity in liquid stored boar semen and its relationships with field fertility[J].Theriogenology,2008,69(6):728-736. [42] WILLIAMS K,FRAYNE J,HALL L.Expression of extracellular glutathione peroxidase type 5(GPX5) in the rat male reproductive tract[J].Molecular Human Reproduction,1998,4(9):841-848. [43] RHEE S G,CHAE H Z,KIM K.Peroxiredoxins:A historical overview and speculative preview of novel mechanisms and emerging concepts in cell signaling[J].Free Radical Biology and Medicine, 2005,38(12):1543-1552. [44] RHEE S G,KANG S W,CHANG T S,et al.Peroxiredoxin,a novel family of peroxidases[J].IUBMB Life, 2001,52(1-2):35-41. [45] FERNANDEZ M C,O'FLAHERTY C.Peroxiredoxin 6 is the primary antioxidant enzyme for the maintenance of viability and DNA integrity in human spermatozoa[J].Human Reproduction,2018,33(8):1394-1407. [46] O'FLAHERTY C.Peroxiredoxins:Hidden players in the antioxidant defence of human spermatozoa[J].Basic and Clinical Andrology,2014,24:4. [47] GONG S,SAN GABRIEL M C,ZINI A,et al.Low amounts and high thiol oxidation of peroxiredoxins in spermatozoa from infertile men[J].Journal of Andrology,2012,33(6):1342-1351. [48] WOO H A,JEONG W,CHANG T S,et al.Reduction of cysteine sulfinic acid by sulfiredoxin is specific to 2-Cys peroxiredoxins[J].Journal of Biological Chemistry,2005,280(5):3125-3128. [49] FISHER A B.Peroxiredoxin 6 in the repair of peroxidized cell membranes and cell signaling[J].Archives of Biochemistry and Biophysic,2017,617:68-83. [50] OZKOSEM B,FEINSTEIN S I,FISHER A B,et al.Absence of peroxiredoxin 6 amplifies the effect of oxidant stress on mobility and SCSA/CMA3 defined chromatin quality and impairs fertilizing ability of mouse spermatozoa[J].Biology of Reproduction,2016,94(3):68. [51] OZKOSEM B,FEINSTEIN S I,FISHER A B,et al.Advancing age increases sperm chromatin damage and impairs fertility in peroxiredoxin 6 null mice[J].Redox Biology,2015,5:15-23. [52] LIU Y,O'FLAHERTY C.In vivo oxidative stress alters thiol redox status of peroxiredoxin 1 and 6 and impairs rat sperm quality[J].Asian Journal of Andrology,2017,19(1):73-79. |