獭兔氟中毒模型的建立及各器官氟含量测定

doi:10.16431/j.cnki.1671-7236.2017.07.036

《中国畜牧兽医》 ›› 2017, Vol. 44 ›› Issue (7): 2160-2164.doi: 10.16431/j.cnki.1671-7236.2017.07.036

獭兔氟中毒模型的建立及各器官氟含量测定

王量¹, 范红结²

1. 山西运城农业职业技术学院, 运城 044000;
2. 南京农业大学动物医学院, 南京 210095

收稿日期:2017-01-02 出版日期:2017-07-20 发布日期:2017-07-22
通讯作者: 范红结 E-mail:fhj-68@sohu.com
作者简介:王量(1981-),男,山西闻喜人,博士,研究方向:动物重大疫病防控,E-mail:wangliangshanxi@126.com
基金资助:
山西运城农职院科学研究项目（2016AB009）

Establishment of the Rex Rabbit Fluorosis Model and Detection of the Fluoride Content in Organs

WANG Liang¹, FAN Hong-jie²

1. Shanxi Yuncheng Agricultural Vocational and Technical College, Yuncheng 044000, China;
2. College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China

Received:2017-01-02 Online:2017-07-20 Published:2017-07-22

摘要/Abstract

摘要：

为研究不同剂量氟化钠对獭兔的影响，试验建立獭兔氟中毒模型并对獭兔血液、骨骼、肝脏、肾脏等器官氟含量进行测定。试验獭兔日龄（30±5） d，体重（1.1±0.2） kg，数量24只，分为3组：对照组、试验Ⅰ组（10 mg/（kg·d）氟化钠组）和试验Ⅱ组（20 mg/（kg·d）氟化钠组），试验共100 d。结果表明，试验第100天测定的骨骼和牙齿氟含量在各组之间均差异显著（P<0.05），且骨骼和牙齿的含氟量随时间和摄入氟剂量的增加而递增；肾脏和肝脏氟含量在各组之间均差异不显著（P>0.05）；试验Ⅰ、Ⅱ组间血液氟含量差异不显著（P>0.05），但都与对照组差异显著（P<0.05）。氟化钠作为氟化物来源可用来建立獭兔自然状态氟中毒症，骨骼和牙齿累积氟能力强，血液、肝脏和肾脏累积氟能力弱。本试验为进一步研究獭兔氟中毒及其防制提供了理论参考。

关键词: 獭兔; 氟化钠; 中毒; 氟含量

Abstract:

In order to study the influence of different doses of sodium fluoride on rex rabbit,rex rabbit fluorosis model was established and the fluorine contents of blood,bone,liver,kidney and other organs in rex rabbit were examined to provide a theoretical reference for the further research. Rex rabbits (age (30±5) days,weight (1.1±0.2) kg) were divided into three groups:Control group,test group Ⅰ (10 mg/(kg·d) NaF group) and test group Ⅱ (20 mg/(kg·d) NaF group). The tests lasted 100 d. The results showed that,on the 100th day,fluoride contents of bone and tooth were significantly different (P<0.05),and they were positively correlated with the time and intake of fluoride;The fluoride contents of kidney and liver were slightly different (P>0.05),and they were not significantly different between both test groups (P>0.05).The fluoride contents of blood were not significantly different between group Ⅰ and group Ⅱ (P>0.05),but both had no significant changes compared with control group (P<0.05). Sodium fluoride as a fluoride source could be used to simulate the natural state of rex rabbit fluorine poisoning. The fluoride accumulating ability in bone and tooth were stronger while the ability in blood,liver and kidney were weaker.

Key words: rex rabbit; NaF; toxicology; fluorosis

中图分类号:

S858.291

王量, 范红结. 獭兔氟中毒模型的建立及各器官氟含量测定[J]. 《中国畜牧兽医》, 2017, 44(7): 2160-2164.

WANG Liang, FAN Hong-jie. Establishment of the Rex Rabbit Fluorosis Model and Detection of the Fluoride Content in Organs[J]. , 2017, 44(7): 2160-2164.

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獭兔氟中毒模型的建立及各器官氟含量测定

Establishment of the Rex Rabbit Fluorosis Model and Detection of the Fluoride Content in Organs

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