SIGIRR对IL-1R/TLRs信号通路的负性调控作用研究进展

doi:10.16431/j.cnki.1671-7236.2016.10.019

摘要/Abstract

摘要：

单免疫球蛋白白介素1受体相关蛋白（SIGIRR）是TIR超家族成员，最新研究表明它可负性调节IL-1R/TLRs受体介导的固有免疫应答，且在感染性疾病、肿瘤及自体免疫病诱导的炎症反应调节上所起的重要作用已经被阐明。作者主要综述了SIGIRR基因和蛋白表达模式在人、小鼠、牛等物种间的差异性，因其结构特异性所具有的对IL-1R/TLRs炎性信号通路的负性调控和具体的调控机理，以及在不同炎性相关疾病的发生和发展中抑制炎性反应的机制，进而为临床的炎性相关疾病治疗提供理论借鉴，同时也拓宽了SIGIRR基因在动物疾病治疗中的应用范围。

关键词: SIGIRR; TLRs; 信号通路; 负性调控

Abstract:

Single immunoglobulin IL-1 related receptor (SIGIRR) is a member of TIR superfamily.Recent evidences suggested that it could negatively modulate ILRs/TLRs-mediated innate immune response,and in particular its important role focused from infectious and intestinal inflammation to autoimmunity or cancer-related inflammation had been illuminated.Here,we summarized our current understanding of the expression patterns of SIGIRR gene and protein in different specises including human,mouse and bovine,its downregulate function of the IL-1/TLRs singal pathway and specific negative regulation mechanism ascribed to its structure specificity,and also its elaborate regulating process related to the occurrence and development of different pathogen condition.And then it can not only provide theoretical references for clinical inflammatory related disease,but also broaden the application scope of SIGIRR gene in the treatment of animal diseases.

Key words: SIGIRR; TLRs; signal path; negative regulation

中图分类号:

Q257

周秋格, 刘畅, 刘玉辉, 赖金伦, 陈颖钰, 郭爱珍, 胡长敏. SIGIRR对IL-1R/TLRs信号通路的负性调控作用研究进展[J]. 《中国畜牧兽医》, 2016, 43(10): 2640-2647.

ZHOU Qiu-ge, LIU Chang, LIU Yu-hui, LAI Jin-lun, CHEN Ying-yu, GUO Ai-zhen, HU Chang-min. Research Progress on the Negative Regulatory Function of SIGIRR to IL-1R/TLRs Signal Pathway[J]. , 2016, 43(10): 2640-2647.

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