炎症反应致肌肉蛋白质降解机理的研究进展

doi:10.16431/j.cnki.1671-7236.2016.09.024

摘要/Abstract

摘要：

骨骼肌消耗是肌肉蛋白质合成减少和（或）分解代谢加快的结果，可发生于多种疾病状态下，如病原菌感染、创伤、肿瘤等。目前越来越多的研究结果表明系统性炎症在肌肉蛋白质降解过程中扮演着重要角色。作者综述了近年来关于炎症反应导致肌肉蛋白质降解机理的研究进展，主要包括泛素—蛋白酶体途径、自噬溶酶体降解途径及PI3K/Akt、p38/MAPK、NF-κB等多条信号通路，为开发新的方法治疗肌肉降解提供参考。

关键词: 骨骼肌消耗; 蛋白质降解; 炎症反应

Abstract:

Skeletal muscle wasting is a consequence of the decrease of muscle protein synthesis and/or degradation acceleration,and often accompanies with various serious diseases,such as pathogen infection,injury and tumor.At present,many studies have shown that the systemic inflammation is playing an important role in the process of muscle wasting.Based on the current literature,we present an overview of the molecular and cellular mechanisms that contribute to the inflammation-induced muscle wasting,mainly including the ubiquitin-proteasome pathway (UPP),autophagy-lysosomal pathway (ALP),PI3K/Akt pathway,p38/MAPK pathway and NF-κB pathway,which hope to offer the guidance for the treatment of skeletal muscle wasting.

Key words: skeletal muscle wasting; protein degradation; inflammation

中图分类号:

R392

王胜军, 刘妍, 刘玉兰, 汪文俊, 张晶. 炎症反应致肌肉蛋白质降解机理的研究进展[J]. 《中国畜牧兽医》, 2016, 43(9): 2379-2387.

WANG Sheng-jun, LIU Yan, LIU Yu-lan, WANG Wen-jun, ZHANG Jing. Research Progress on the Mechanisms of Inflammation-induced Muscle Protein Degradation[J]. , 2016, 43(9): 2379-2387.

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