脂联素及其受体的研究进展及在生殖中的作用

doi:10.16431/j.cnki.1671-7236.2015.07.030

摘要/Abstract

摘要： 脂联素是一种由脂肪组织分泌的具有多种生物学功能的特殊蛋白,在增强脂肪酸氧化、抗炎症反应、抗糖尿病等方面起重要作用。脂联素通过AdipoR1和AdipoR2这两种受体的介导经过AMPK、PPAR、p38MAPK等信号通路来发挥生物学作用。脂联素及其受体AdipoR1和AdipoR2能在多种组织器官中表达,AdipoR1主要在肌肉组织中表达,AdipoR2则高表达于肝脏组织。此外,脂联素及其受体还能在下丘脑、垂体、子宫、胚胎等多种生殖腺和生殖组织中表达,说明脂联素在调控动物生殖及胚胎生长发育方面起重要作用。

关键词: 脂联素; 脂联素受体; 表达调控; 合成分泌; 信号通路; 生殖调控

Abstract: Adiponectin is a special protein which is secreted by adipose tissue and has many kinds of biological functions that play an important role in enhancing fatty acid oxidation,inflammation reaction and anti diabetes ect.Adiponectin mediated by AdipoR1 and AdipoR2 via AMPK,PPAR,p38MAPK signal pathway plays an important role.Adiponectin and its receptors AdipoR1 and AdipoR2 express in many tissues,AdipoR1 is mainly expressed in muscle tissue,AdipoR2 is highly expressed in liver tissue.In addition,adiponectin and its receptors also expressed in the hypothalamus,pituitary,uterus,embryo and other reproductive glands and tissues,which indicate that adiponectin plays an important role in regulating animal reproduction and embryo growth and development.

Key words: adiponectin; adiponectin receptor; expression regulation; synthesis and secretion; signal pathway; reproductive regulation

中图分类号:

R589.2

白曼, 赵佳, 展微, 孙丽敏, 姜怀志. 脂联素及其受体的研究进展及在生殖中的作用[J]. , 2015, 42(7): 1830-1835.

BAI Man, ZHAO Jia, ZHAN Wei, SUN Li-min, JIANG Huai-zhi. Research Progress on Adiponectin and its Receptors and their Roles in Reproduction[J]. , 2015, 42(7): 1830-1835.

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