传染性支气管炎病毒的分子生物学特性及其弱毒疫苗的研究进展

doi:10.16431/j.cnki.1671-7236.2015.06.039

《中国畜牧兽医》---唯一指定的官方网站 ›› 2015, Vol. 42 ›› Issue (6): 1587-1591.doi: 10.16431/j.cnki.1671-7236.2015.06.039

传染性支气管炎病毒的分子生物学特性及其弱毒疫苗的研究进展

闫艺婷^1,2,3, 勾肖晶^1,2, 刘静^1,3, 黄亚明^1,2, 杨激辉^1,2,3, 刘兴友^1,2,3

1. 河南科技学院动物科学学院, 新乡 453003;
2. 畜禽智能化清洁生产河南省工程实验室, 新乡 453003;
3. 动物病毒病防控与药残分析河南省重点学科开放实验室, 新乡 453003

收稿日期:2014-11-20 出版日期:2015-06-20 发布日期:2015-07-23
通讯作者: 刘兴友 E-mail:lxy63@hist.edu.cn
作者简介:闫艺婷(1989-),女,河南安阳人,硕士生,研究方向:动物分子病毒学,E-mail:992495169@qq.com
基金资助:
国家自然科学基金(30771601);河南省高校科技创新人才支持计划(2009HASTIT010)

Research Progress on Molecular Biological Characteristics and Attenuated Vaccine of Infectious Bronchitis Virus

YAN Yi-ting^1,2,3, GOU Xiao-jing^1,2, LIU Jing^1,3, HUANG Ya-ming^1,2, YANG Ji-hui^1,2,3, LIU Xing-you^1,2,3

1. College of Animal Science, Henan Institute of Science and Technology, Xinxiang 453003, China;
2. Henan Higher Education Engineering Discipline Intelligent Cleaner Production of Livestock, Xinxiang 453003, China;
3. Animal Viral Disease Control and Residual Analysis Henan Higher Education Key Discipline Open Laboratory, Xinxiang 453003, China

Received:2014-11-20 Online:2015-06-20 Published:2015-07-23

摘要/Abstract

摘要： 传染性支气管炎是一种急性、高度接触性传染病,被世界动物卫生组织(OIE)列为B类疫病,对世界养禽业的发展造成了严重威胁.目前,传染性支气管炎的主要预防措施仍然是接种疫苗,但由于传染性支气管炎病毒具有血清型众多、变异速度快且交叉保护性弱等特点,使得传染性支气管炎的防制一直是养禽业面临的重大难题.文章主要对传染性支气管炎病毒的分子生物学特征及其弱毒疫苗的发展历程和免疫策略等方面进行了阐述,以期为新型传染性支气管炎弱毒疫苗的开发及应用提供科学参考.

关键词: 传染性支气管炎病毒; S蛋白; M蛋白; N蛋白; 弱毒疫苗

Abstract: Infectious bronchitis (IB) is an acute and susceptible infectious disease,which has been classified as B loemia and causes a grave threat to the poultry industry.Now,the primary prevention measures of IB are vaccine inoculation.With the diversity of infectious bronchitis virus (IBV) serotype and easy variation,and the weakness of cross protection,the prevention and control of IB were a major problem in poultry industry.In this ariticle,it summarized the molecular biological characteristics, and the development and immunization strategy of the attenuated vaccine of IB to provide scientific references for the research and application of IB attenuated vaccine.

Key words: infectious bronchitis virus; S protein; M protein; N protein; attenuated vaccine

中图分类号:

S852.65

闫艺婷, 勾肖晶, 刘静, 黄亚明, 杨激辉, 刘兴友. 传染性支气管炎病毒的分子生物学特性及其弱毒疫苗的研究进展[J]. 《中国畜牧兽医》---唯一指定的官方网站, 2015, 42(6): 1587-1591.

YAN Yi-ting, GOU Xiao-jing, LIU Jing, HUANG Ya-ming, YANG Ji-hui, LIU Xing-you. Research Progress on Molecular Biological Characteristics and Attenuated Vaccine of Infectious Bronchitis Virus[J]. , 2015, 42(6): 1587-1591.

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传染性支气管炎病毒的分子生物学特性及其弱毒疫苗的研究进展

Research Progress on Molecular Biological Characteristics and Attenuated Vaccine of Infectious Bronchitis Virus

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