LncRNA在动物科学中的研究进展

doi:10.16431/j.cnki.1671-7236.2015.06.015

摘要/Abstract

摘要： 长链非编码RNA(long non-coding RNA,LncRNA)是一类长度大于200 nt的非编码RNA,能够存在于细胞核和细胞质中.LncRNA能够以顺式和反式作用方式调节基因表达,是一类重要的基因表达调节分子.LncRNA参与细胞分化发育、X染色体失活、肿瘤、免疫、神经系统和心血管系统疾病等多种生物过程和疾病的调控,具有重要的研究价值.作者主要对LncRNA的分类和来源、作用机制、研究现状及其在畜牧兽医中的研究情况进行了综述,为LncRNA在兽医和畜牧业科学中的研究和应用提供参考.

关键词: 长链非编码RNA; 基因表达调控; 发育; 免疫

Abstract: Long noncoding RNA (LncRNA) constituted a novel class of non-protein coding transcripts longer than 200 nt,and were localized in nuclear and cytoplasmic.LncRNA can regulate gene expression in cis and trans,were recognized as a kind of key regulatory molecules.LncRNA were involved in various aspects of cell biology and disease,such as cell differentiation,X chromosome inactivation,cancer,immune,neurological and cardiovascular system disorders.In this paper,we mainly summarized the origions,research status and action mechanism of LncRNA,as well as overseas and domestic research status of LncRNA in animal husbandry and veterinary.Finally,the potential research and application prospects of LncRNA in animal science were put forward.

Key words: long non-coding RNA; gene expression regulation; development; immune

中图分类号:

Q522

赵健康, 臧长江, 姜保春. LncRNA在动物科学中的研究进展[J]. 《中国畜牧兽医》---唯一指定的官方网站, 2015, 42(6): 1424-1428.

ZHAO Jian-kang, ZANG Chang-jiang, JIANG Bao-chun. Research Progress on LncRNA in Animal Science[J]. , 2015, 42(6): 1424-1428.

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