苦玄参提取物对仔猪血清生化指标及免疫指标的影响

doi:10.16431/j.cnki.1671-7236.2018.10.011

Abstract

Abstract:

This trial was conducted to investigate the effect of dietary Picria fel-tarrae Lour extracts on serum biochemical indexes,anti-oxidant indexes and some immune indexes of piglets to provide theoretical basis and production guidance for rational utilization of Picria fel-terrae Lour extracts in the production of piglets.A total of 250 healthy cross-breed pigs (Duroc×Landrace×Yorkshire) at 28-35 days were selected and randomly divided into 5 groups (groups A,B,C,D and E) with 5 replicates per treatment and 10 piglets per replicate.The piglets in groups A,B and C were fed basal diet supplemented with high (3.5 g/kg),middle (1.75 g/kg)and low doses (0.875 g/kg) Picria fel-tarrae Lour extracts,respectively,that in group D fed basal diet with 4.0 g/kg Qibusan,while that in group E was fed basal diet.The pre-feeding period was 7 d and the trial period was 30 d.Blood samples were obtained from the anterior vena cava by randomly selecting 10 piglets from each group on the 14th day after administration and the 14th day after drug withdrawal to analyze the biochemical,antioxidant and immune indexes.The results showed as follows:①There was no significant difference in blood biochemical indexes among experimental groups,indicating Picria fel-terrae Lour extracts had no adverse effects on glucose metabolism,lipid metabolism and digestive system in piglets.②From the antioxidant indexes,after administration for 14 d,NO content in group B was extremely significantly higher than that of other groups (P < 0.01),and the contents of T-AOC in group A was extremely significantly higher than that of other groups (P < 0.01),and that in groups B and D were extremely significantly or significantly higher than groups C and E (P < 0.01;P < 0.05).At 14th day after drug withdrawal,the contents of GSH in group E was significantly higher than that of groups B,C and D (P < 0.05).There was no significant difference in other indexes among all groups (P > 0.05).③From the immune indexes,after administration for 14 d,the level of IgG in group B was extremely significantly higher than that in other groups (P < 0.01) and the content of IL-6 in group A was significantly higher than that in groups B,D and E (P < 0.05).At 14th day after drug withdrawal,there was no significant difference in immune indexes among all groups (P > 0.05).In conclusion,the dietary supplementation of 0.875 to 3.5 g/kg Picria fel-tarrae Lour extracts had a good effect on enhancing the antioxidant function and improving the immune level of piglets with no adverse effects on piglets health.

Key words: piglets; Picria fel-tarrae Lour extracts; serum biochemical indexes; antioxidant indexes; immune indexes

CLC Number:

S828

LIU Yancan, LI Xiaoyu, CHEN Zhongwei, DUAN Qunpeng, ZHANG Ning, GUO Xuan, HUANG Hongye, HU Tingjun, HE Ying. Effect of Dietary Picria fel-tarrae Lour. Extracts on Serum Biochemical Indexes and Immune Function of Piglets[J]. , 2018, 45(10): 2743-2751.

References

[1] 国家药典委员会.《中华人民共和国药典》[M].2010年版.北京:中国中药医药科技出版社,2010.NATIONAL PHARMACOPOEIA COMMISSION.Pharmacopoeia of the People's Republic of China[M]2010 Edition.Beijing:Chinese Medicine Medical Science and Technology Press,2010.(in Chinese)
[2] 张银娣,刘小浩.绵毛黄芪苷和苦玄参苷的中枢抑制作用[J].南京医科大学学报(自然科学版),1990,10(1):17-19.ZHANG X D,LIU X H.Depressive effects of SK and PIA on CNS in mice[J].Journal of Nanjing Medical University(Natural Science),1990,10(1):17-19.(in Chinese)
[3] 陈君,甄汉深,韦建华.苦玄参叶抗炎药理作用研究[J].海峡药学,2013,25(2):23-25.CHEN J,ZHEN H S,WEI J H.Study on anti-inflammatory of Picria fel-tarrae' leaves[J].Strait Pharmaceutical Journal,2013,25(2):23-25.(in Chinese)
[4] 康茜.两株华南毛蕨内生真菌及苦玄参抗菌活性成分的研究[D].广州:广东药科大学,2017.KANG X.Study on antibacterial constituents of two endophytic fungi from Cyclosorus parasiticus and Picria fel-terrae Lour[D].Guangzhou:Guangdong Pharmaceutical University,2017.(in Chinese)
[5] 杨翠,廖玉英,韦风英,等.苦玄参提取物对广西麻鸡生长性能及免疫器官指数的影响[J].粮食与饲料工业,2016,12(9):53-56.YANG C,LIAO Y Y,WEI F Y,et al.Effect of diet with Picria fel-terrae Lour extracts on growth performance and immune organ index of Guangxi partridge chickens[J].Cereal and Feed Industry,2016,12(9):53-56.(in Chinese)
[6] 杨翠,胡庭俊,杨剑,等.苦玄参提取物对广西麻鸡血清生化指标及免疫功能的影响[J].中国畜牧兽医,2017,44(1):65-73.YANG C,HU T J,YANG J, et al.Effect of dietary Picria fel-terrae Lour extracts on serum biochemical indexes and immune function of Guangxi partridge chickens[J].China Animal Husbandry & Veterinary Medicine,2017,44(1):65-73.(in Chinese)
[7] 周玉香,吕玉玲,王洁,等.血液生化指标在动物生产与营养调控研究中的应用概况[J].畜牧与饲料科学,2012,33(Z1):72-74.ZHOU Y X,LV Y L,WANG J,et al.Application survey of blood biochemical indices in the studies of animal production and nutritional regulation[J].Animal Husbandry and Feed Science,2012,33(Z1):72-74.(in Chinese)
[8] 蔡旭滨,陈凌锋,檀新珠,等.太子参茎叶多糖对断奶仔猪生长性能和血清抗氧化指标、免疫指标及生化指标的影响[J].动物营养学报,2016,28(12):3867-3874.CAI X B,CHEN L F,TAN X Z,et al.Effects of Radix pseudostellariae stem and leaf polysaccharide on growth performance,antioxidant indexes,immune indexes and biochemical indexes in serum of weaned piglets[J].Chinese Journal of Animal Nutrition,2016,28(12):3867-3874.(in Chinese)
[9] 宋荣渊,王洪荣,王欢莉,等.不同能氮同步化释放日粮对泌乳奶牛生产性能和血液生化指标的影响[J].饲料工业,2010,31(23):38-40.SONG R Y,WANG H R,WANG H L,et al.Effects of different energy nitrogen synchronous release diet on production performance and blood biochemical indexes of lactating dairy cows[J].Feed Industry,2010,31(23):38-40.(in Chinese)
[10] 刘科,施赫赫,陈淦,等.融水小型猪F1代的血常规、血生化与电解质指标[J].中国比较医学杂志,2015,25(3):35-41.LIU K,SHI H H,CHEN G,et al.Detection and analysis of blood parameter,blood biochemical and electrolyte indices in F1 generation of Rongshui miniature pig[J].Chinese Journal of Comparative Medicine,2015,25(3):35-41.(in Chinese)
[11] 侯成立,季海峰,周雨霞,等.植物乳杆菌对断奶仔猪生产性能和生化指标的影响[J].饲料研究,2011,12:14-16.HOU C L,JI H F,ZHOU Y X,et al.Effects of Lactobacillus plantarum on performance and biochemical indexes of weaned piglets[J].Feed Research,2011,12:14-16.(in Chinese)
[12] JONES D P.Redox potential of GSH/GSSG couple:Assay and biological significance[J].Methods Enzymol,2002,348(1):93-112.
[13] 姜宁,杨坤,张爱忠,等.谷胱甘肽对育肥羊机体抗氧化能力的影响[J].饲料工业,2015,36(23):45-48.JIANG N,YANG K,ZHANG A Z,et al.Effect of glutathione on antioxidant ability in fattening sheep[J].Feed Industry,2015,36(23):45-48.(in Chinese)
[14] 孙国祥,张旭,张成国,等.谷胱甘肽在动植物领域的应用研究进展[J].安徽农业科学,2018,8:42-45.SUN G X,ZHANG X,ZHANG C G,et al.Application of glutathione in animal and plant fields[J].Anhui Agricultural Sciences,2018,8:42-45.(in Chinese)
[15] 傅帅,轩振,李鸿博,等.复方中草药制剂对肉仔鸡生产性能和抗氧化功能影响的研究[J].粮食与饲料工业,2016,12(2):61-66.FU S,XUAN Z,LI H B,et al.Effect of Chinese herbal prescription on production performance and antioxidant activity of broilers[J].Cereal and Feed Industry,2016,12(2):61-66.(in Chinese)
[16] 倪海球,孙杰,杨玉娟,等.棉籽粕膨化前后品质变化及对生长育肥猪生长性能、血清生化指标及营养物质表观消化率的影响[J].动物营养学报,2018,30(5):1936-1949.NI H Q,SUN J,YANG Y J,et al.Quality changes of cottonseed meal before and after expansion and their effects on growth performance,serum biochemical indices and nutrient apparent digestibility of growing-finishing pigs[J].Chinese Journal of Animal Nutrition,2018,35(5):1936-1949.(in Chinese)
[17] COOKE J P.Flow,NO,and atherogenesis[J].Proceedings of the National Academy of Sciences of USA,2003,100(3):768.
[18] OELZE M,WARNHOLTZ A,FAULHABER J R,et al.NADPH oxidase accounts for enhanced superoxide production and impaired endothelium-dependent smooth muscle relaxation in BKβ1^-/- mice[J].Arteriosclerosis Thrombosis & Vascular Biology,2006,26(8):1753-1759.
[19] 曾庆国,胡锦文,涂杨梅.中药免疫增强剂对断奶仔猪生长性能和免疫功能的影响[J].江西畜牧兽医杂志,2006,5:7-8.ZENG Q G,HU J W,TU Y M.Effects of Chinese herbal immunopotentiator on growth performance and immune function of weaned piglets[J].Jiangxi Journal of Animal Husbandry & Veterinary Medicine,2006,5:7-8.(in Chinese)
[20] 王照,王磊,李天松,等.动物干扰素的研究进展[J].中国动物检疫,2012,29(2):71-73.WANG Z,WANG L,LI T S,et al.Research progress on animal interferon[J].Chinese Journal of Animal Quarantine,2012,29(2):71-73.(in Chinese)
[21] 刘佳,单安山,孙进华.白细胞介素-2的研究进展与应用[J].黑龙江畜牧兽医,2009,21:19-20.LIU J,SHAN A S,SUN J H.Research progress and application of interleukin-2[J].Heilongjiang Animal Husbandry and Veterinary Medicine,2009,21:19-20.(in Chinese)
[22] 张玲华,郭勇,田兴山,等.白细胞介素-6的分子生物学研究进展及其在畜禽业中的应用前景[J].中国畜牧兽医,2005,32(2):31-33.ZHANG L H,GUO Y,TIAN X S,et al.Research progress of molecular biology of interleukin-6 and its application prospect in livestock and poultry in-dustry[J].China Animal Husbandry & Veterinary Medicine,2005,32(2):31-33.(in Chinese)
[23] 姜卫星,袁文军,李伟,等.中草药添加剂对育肥猪生长性能和免疫功能的影响[J].中国畜牧兽医,2011,38(5):15-19.JIANG W X,YUAN W J,LI W,et al.Effects of Chinese herbal additives on growth performance and immune function of finishing pigs[J].China Animal Husbandry & Veterinary Medicine,2011,38(5):15-19.(in Chinese)
[24] SIEGAL F P,KADOWAKI N,SHODELL M,et al.The nature of the principal type 1 interferon-producing cells in human blood[J].Science,1999,284(5421):1835-1837.

Effect of Dietary Picria fel-tarrae Lour. Extracts on Serum Biochemical Indexes and Immune Function of Piglets

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments

[1]	WANG Yuan, WANG Wenwen, AN Xiaoping, QI Jingwei. Effects of Dietary Fermented Soybean Meal Replacement on Growth Performance, Digestive Enzyme,and Microbita Composition in Weaned Piglets [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(1): 115-124.
[2]	WANG Shuaijie, TAN Zihan, LI Hanbo, SUN Xiangxue, AI Sihan, WANG Lei, ZHAO Di, HOU Yongqing. Effects of Quercetin on Intestinal Morphology, Antioxidant Function and Jejunal Lipid Metabolism Gene Expression in Piglets with Porcine Epidemic Diarrhea Virus [J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(9): 3391-3399.
[3]	WEI Jia, BAI Qin, LUO Xiaolin, GUAN Jiuqiang, AN Tianwu, ZHAO Hongwen, TAN Wu, LI Huade, XIE Rongqing, SHA Quan, JIANG Mingfeng, ZHANG Xiangfei. Effects of Different Weaning Strategies on Growth, Serum Biochemical Indexes and Antioxidant Capacity of Yak Calves [J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(9): 3400-3410.
[4]	WANG Manli, TAN Zihan, WANG Shuaijie, LI Qian, ZENG Yitong, WANG Lei, ZHAO Di, ZHANG Qian, HOU Yongqing. Effects of Quercetin on Growth Performance, Blood Biochemical Indexes and Intestinal Absorption and Barrier Function in Piglets Infected with PEDV [J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(9): 3411-3418.
[5]	CHEN Lihong, ZHAO Mengdi, LIU Keyuan, NING Haoran, CUI Kai, LI Guangyu, SUN Weili. Study on Optimum Dietary Metabolizable Energy Level of Male Pheasants from 13 to 17 Weeks of Age [J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(8): 2943-2952.
[6]	CHEN Xueying, WANG Huisheng, WU Jie, DENG Bo, DIAO Xinping. Effects of Dietary Bacillus licheniformis and Bacillus amyloliquefaciens on Growth Performance and Blood Indicators of Weaned Piglets [J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(7): 2547-2556.
[7]	REN Jianming, JI Peng, ZHANG Xiaosong, WEI Yanming, ZHU Xiaopeng, ZHU Yueming. Effects of Jianpi Xiaodao Chinese Herbal Compound on Growth Performance, Rumen Fermentation Parameters and Serum Indexes of 6-month-old Simmental Crossbred Cattles [J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(7): 2593-2600.
[8]	ZHANG Rui, ZHOU Weiqiang, MA Yue, WU Jianping, LEI Zhaomin. Effects of Oregano Essential Oil and Colostrum Complex on Growth Performance, Serum Indicators Related Antioxidant and Immune in Opportunity Piglets [J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(4): 1314-1321.
[9]	WANG Chaopu, MA Xianyong, TIAN Zhimei, YU Miao, LIU Zhichang, DENG Dun, RONG Ting, TI Junling, SONG Min, ZHANG Huihua. Effects of Compound Chinese Medicine Fermentation Powder on Growth Performance,Nutrient Apparent Digestibility,Antioxidant Function and Immune Function of Weaned Piglets [J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(4): 1322-1331.
[10]	YANG Zhiwei, LI Zhixing, HUANG Tao, HAO Kexing, WANG Jing, HU Guangdong. Effects of Early Weaning and Transfer on Behavior, Growth Performance and Blood Indexes of Piglets [J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(3): 904-912.
[11]	BAI Peitian, KONG Jiamei, PEI Ting, CHENG Zhixue, REN Yuhong. Effects of Compound Microecological Preparation on Growth Performance, Immune Function and Caecal Flora Structure of Weaned Piglets [J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(3): 942-952.
[12]	WANG Jiaxin, HAN Yunsheng, CAI Hongying, WEN Zhiguo, XU Xin, ZHAO Zitao, MENG Kun, YANG Peilong. Effects of Bacillus licheniformis on Growth Performance, Serum Biochemical Indexes and Intestinal Morphology of Broilers [J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(12): 4593-4603.
[13]	ZHANG Qiang, LIU Zhenni, LIAO Qiang, LEI Xiaowen, KONG Zhiwei, XIE Hualiang, TAN Donghai, LI Jianjun, ZHONG Yunping. Effects of Fermented Andrographis Powder on Production Performance, Serum Biochemical Indexes, Immune Related Indexes, Antioxidant Indexes and Fatty Acid Contents of Muscle in Muscovy Ducks [J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(12): 4614-4624.
[14]	GUO Linxia, MA Kewei, FENG Zhihua, LIU Yanci, LIU Guanzhong, LI Qingyan, GONG Sumei, LI Shupeng, ZHAO Guoxian. Effects of Jujube Polysaccharide on Growth Performance and Immune Indexes of Immunosuppressive Egg-type Chicks [J]. China Animal Husbandry and Veterinary Medicine, 2021, 48(9): 3264-3272.
[15]	SU Lingling, TUOHUTI Ajide, ZHANG Guoting, PAREHATIJIANG Wufuer, XIE Lirong, WANG Qiong, ABULAITI Sulaiman, NUERNISA Molaniyazi, REN Juan, ZHANG Yuhua, XIAO Hailong, XIE Peng, XIAO Haixia. Effects of Whole Corn Silage and Supplementary Sodium Bicarbonate on Growth Performance,Digestibility,Serum Biochemical Indexes and Economic Benefits in Jiangyue Donkey [J]. China Animal Husbandry and Veterinary Medicine, 2021, 48(7): 2388-2396.